Results 61 to 70 of about 99,652 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of geographical and agroclimatic location on phytocompounds and antioxidant activity of Moringa oleifera leaves

Journal of Advanced Biotechnology and Experimental Therapeutics
Moringa oleifera is known has high phytochemical content and biological activity. Differences in geographic and agroclimate can influence the phytochemical content and bioactivity of plants. This study aims to analyze differences in phytochemical content,
Eka Sukmawaty, Ahyar Ahmad, Abdul Karim, Zaraswati Dwyana, Harningsih Karim, Siti Halimah Larekeng, Masriany Masriany, Zulkarnain Zulkarnain, Devi Armita, Rahmat Fajrin Alir   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Using Electro-peroxone Process to Remediate Soil Contaminated with Phenol [PDF]

Iranica Journal of Energy and Environment
Industrial processes are among human activities that cause production of a large volume of wastewater containing organic pollutants such as phenol and its derivatives.
E. Faghih Nasiri, F. Qaderi, S. M. Rahmaninezhad   +2 more
doaj   +1 more source

THE DETERMINATION OF PHENOL. [PDF]

Journal of the American Chemical Society, 1905
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openaire   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Comparative Study of Microwave-Assisted and Supercritical Drying for the Synthesis of Highly Porous Silica Aerogel: A Promising Adsorbent for Phenol Removal from Wastewater [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The removal of phenol from wastewater is crucial because of its harmful influences on human health, soil quality, and aquatic ecosystems. Among the different methods used for phenol removal, adsorption has gained popularity as an affordable and effective
Hamid Kazemi Hakki, Aref Ghaderi, Pouya Nagshini, Hossein Alinezhad Avalzali, Masoume Sedighi Rad   +4 more
doaj   +1 more source

Phenol Biodegradation by Two Xenobiotics-Tolerant Bacteria Immobilized in Polyethylene Oxide Cryogels [PDF]

, 2009
Biofilms were formed on poly(ethylene oxide) (PEO) cryogels by using bacteria cultured from xenobiotics polluted environments and their phenol biodegrading capability was studied.
Dimkov, Raycho, Selenska-Pobell, Sonja, Bogdanov, Vladimir, Tsvetanov, Christo, Satchanska, Galina, Golovinsky, Evgeny, Petrov, Petar, Topalova, Yana, Gorbovskaya, Alla   +8 more
core  

Phenol-Enhanced Depolymerization and Activation of Kraft Lignin in Alkaline Medium

, 2019
Phenolation is an effective method to improve the reactivity of lignin in the synthesis of lignin–phenol–formaldehyde (LFP) resin. Previous lignin phenolation was almost exclusively catalyzed by acid.
Xuejun Pan (2404789), Xuejun Pan, Linhuo Gan, Linhuo Gan (6640817)   +3 more
core   +1 more source