Results 41 to 50 of about 493,957 (307)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Diet quality and food insecurity in Lebanon: insights into dietary diversity, mediterranean diet adherence, and phytochemical intake among adults

Scientific Reports
Lebanon is undergoing a nutrition transition that increases the risk of nutritional deficiencies and noncommunicable diseases. This study assessed diet quality—measured by adherence to the Mediterranean diet (MD), household dietary diversity (HDD), and ...
Myriam Abboud, Maroun Khattar, Nikolaos Tzenios, Rana Rizk, Maha Hoteit   +4 more
doaj   +1 more source

The economic crisis in Lebanon and adolescent nutritional health: a multi-mycotoxin exposure and risk assessment of stunting and thinness

Frontiers in Nutrition
IntroductionThe Lebanese diet, rich in cereals, pulses, and dairy, is highly vulnerable to mycotoxin contamination due to the country’s temperate climate and humidity.
Maha Hoteit, Maha Hoteit, Maha Hoteit, Aya Abou Yassin, Rouaa Daou, Nikolaos Tzenios, Joyce Haddad, Bilal Hotayt, Bilal Hotayt, André El Khoury   +9 more
doaj   +1 more source

PHENOL COEFFICIENTS

American Journal of Public Health, 1921
The author states that a phenol coefficient indicates relative germicidal efficiency under laboratory conditions only, and has no practical value. Users of disinfectants ordinarily “follow directions,” and employ the dilutions recommended by the manufacturers.
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Photocatalytic Phenol Degradation by Silica-Modified Titanium Dioxide

Applied Sciences, 2021
Titanium dioxide (TiO2) has been widely applied as a photocatalyst for wastewater treatment due to its high photocatalytic activity and it can remove various harmful organic pollutants effectively.
Diana Rakhmawaty Eddy, Soraya Nur Ishmah, Muhamad Diki Permana, M. Lutfi Firdaus, Iman Rahayu, Yaser A. El-Badry, Enas E. Hussein, Zeinhom M. El-Bahy   +7 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of geographical and agroclimatic location on phytocompounds and antioxidant activity of Moringa oleifera leaves

Journal of Advanced Biotechnology and Experimental Therapeutics
Moringa oleifera is known has high phytochemical content and biological activity. Differences in geographic and agroclimate can influence the phytochemical content and bioactivity of plants. This study aims to analyze differences in phytochemical content,
Eka Sukmawaty, Ahyar Ahmad, Abdul Karim, Zaraswati Dwyana, Harningsih Karim, Siti Halimah Larekeng, Masriany Masriany, Zulkarnain Zulkarnain, Devi Armita, Rahmat Fajrin Alir   +9 more
doaj   +1 more source

Biodegradation Potential and Putative Catabolic Genes of Culturable Bacteria from an Alpine Deciduous Forest Site

Microorganisms, 2021
Microbiota from Alpine forest soils are key players in carbon cycling, which can be greatly affected by climate change. The aim of this study was to evaluate the degradation potential of culturable bacterial strains isolated from an alpine deciduous ...
Caroline Poyntner, Andrea Kutzner, Rosa Margesin   +2 more
doaj   +1 more source