Results 121 to 130 of about 3,745,370 (303)
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Dissipation-induced anomalous multicritical phenomena
We explore the influence of dissipation on a paradigmatic driven-dissipative model where a collection of two level atoms interact with both quadratures of a quantum cavity mode. The closed system exhibits multiple phase transitions involving discrete and
Chitra, R. +3 more
core +2 more sources
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The Explanation of Second Analogy (Principle of Causality) in Critique of Pure Reason [PDF]
حکمت اسرا, 2014 Kant's attention to the causality is due to conflicts of processes of objectification in subjective concept of causality. The question has always been along the doubts of philosophers in modern era about the duality of body and soul. Philosophers such as
mohammadhadi hazeri +1 more
doaj
Coherent phenomena in mesoscopic systems
A mesoscopic system of cylindrical geometry made of a metal or a semiconductor is shown to exhibit features of a quantum coherent state. It is shown that magnetostatic interaction can play an important role in mesoscopic systems leading to an ordered ...
Cheung H-F +6 more
core +2 more sources
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Cyclic sieving is a well-known phenomenon where certain interesting polynomials, especially $q$-analogues, have useful interpretations related to actions and representations of the cyclic group.
Rao, Sujit, Suk, Joe
core +1 more source
Critical Phenomena in Hyperbolic Space
In this paper we study the critical behavior of an $N$-component ${\phi}^{4}$-model in hyperbolic space, which serves as a model of uniform frustration.
Jeevanesan, Bhilahari +2 more
core +2 more sources