Results 61 to 70 of about 1,375,072 (318)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Missing Shapiro steps in topologically trivial Josephson junction on InAs quantum well

open access: yesNature Communications, 2021
Recent observations of missing odd Shapiro steps have been interpreted in the context of topological superconductivity. Here, the authors observe missing odd Shapiro steps in topologically trivial Josephson junctions due to high transparency of the ...
Matthieu C. Dartiailh   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Towards a corpuscular model of optical phenomena [PDF]

open access: yes, 2011
This thesis presents a collection of event-by-event models that simulate fundamental optical experiments. The simulation approach is completely based on the experimental facts.
Jin, Fengping, Jin, Fengping,
core  

Measuring core bereavement phenomena [PDF]

open access: yes, 1997
As part of a longitudinal study of bereavement phenomena in three groups, bereaved spouses, bereaved adult children and bereaved parents, scale development was carried out using a pool of bereavement phenomenology questions administered prospectively ...
Middleton, Warwick   +7 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Bogen and Woodward’s data-phenomena distinction, forms of theory-ladenness, and the reliability of data [PDF]

open access: yes, 2009
Some twenty years ago, Bogen and Woodward challenged one of the fundamental assumptions of the received view, namely the theory-observation dichotomy and argued for the introduction of the further category of scientific phenomena.
Schindler, Samuel
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dissociation of phantom limb phenomena from stump tactile spatial acuity and sensory thresholds [PDF]

open access: yes, 2005
Most amputees experience phantom limb sensations and/or phantom limb pain as well as residual limb (stump) pain that are resistant to treatment. Phantom phenomena are not homogeneous; each patient presents with a unique combination of spontaneous or ...
Katz, Joel   +2 more
core  

Quantized phenomena in graphene nanoripples [PDF]

open access: yes, 2016
In this study, a previously published continuum model for a stretched sheet was adapted to the case of a compressed sheet to understand the geometry of graphene nanoripples.
Liu, F (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech, Inst Mech, Beijing 100190, Peoples R China.   +2 more
core   +1 more source

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