Results 91 to 100 of about 36,717 (342)

The Treatment of Anxiety [PDF]

, 1967
Rational therapy requires accurate diagnosis. When we apply this precept to anxiety a fundamental question arises. Is anxiety an illness in terms of the now berated medical model which holds that an illness has a cause, a natural history, and hopefully a
McGinnis, Nancy H., Schwab, John J.
core   +1 more source

Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation

Cell Death and Disease, 2011
Chemotherapy resistance poses severe limitations on the efficacy of anti-cancer medications. Recently, the notion of using novel combinations of ‘old’ drugs for new indications has garnered significant interest.
D. Zong, P. Hååg, I. Yakymovych, R. Lewensohn, K. Viktorsson   +4 more
semanticscholar   +1 more source

A Tale of Two Designs: Comparing Design of Experiment Strategies for Reaction Optimization

Chemistry–Methods, EarlyView.
The application of Design of Experiments (DoE) significantly accelerates the optimization of reaction conditions for previously unreported transformations. DoE achieves this by focusing experimental efforts, enabling efficient exploration of the so‐called experimental space.
Linda Romano, Veronica Ceccucci, Leonardo Tensi, Claudio Santi, Luca Sancineto   +4 more
wiley   +1 more source

Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects

BMC Psychiatry, 2009
Background Although much progress has been made on antipsychotic drug development, precise mechanisms behind the action of typical and atypical antipsychotics are poorly understood.
Song Jonathan, Llenos Ida C, Weis Serge, Higgs Brandon W, Choi Kwang H, Dulay Jeannette R, Yolken Robert H, Webster Maree J   +7 more
doaj   +1 more source

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

Nature Communications, 2020
So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF ...
Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L. Will, Divita Garg, Claudia Sippel, Tobias G. Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler   +14 more
doaj   +1 more source

Determination and Correlation of Anticardiolipin Antibody with High Sensitivity C- reactive Proteins and its Role in Predicting Short Term Outcome in Patients with Acute Coronary Syndrome [PDF]

, 2011
Anticardiolipin antibody (aCL) is considered to be an independent risk factor while high sensitivity C reactive protein (hsCRP) is an established marker for coronary artery disease. This study was conducted to determine levels of aCL antibodies and hsCRP,
Gupta, V, Kapoor, N, Kashyap, JR, Malhotra, AS, Mehta, J, Sachdev, A, Sharma, R   +6 more
core  

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

Proceedings of the National Academy of Sciences of the United States of America, 1996
In Alzheimer disease (AD) the microtubule-associated protein tau is redistributed exponentially into paired helical filaments (PHFs) forming neurofibrillary tangles, which correlate with pyramidal cell destruction and dementia.
C. Wischik, P. Edwards, Robert Y.K. Lai, M. Roth, C. Harrington   +4 more
semanticscholar   +1 more source

Few Steps, Big Impact: Recent Advances in the Streamlined Synthesis of Multiply Chiral Heterohelicenes with Tunable Optoelectronic Properties

Chemistry–Methods, EarlyView.
Heterohelicenes with multiple chiral axes have the potential to drive next‐generation technologies due to their unique structural and optoelectronic features. This review highlights innovative short‐step synthetic strategies for double and triple heterohelicenes, emphasizing their ease of preparation and valuable (chir)optical features, along with high
Mohamed S. H. Salem, Shinobu Takizawa
wiley   +1 more source

Pancreatic ductal adenocarcinoma [PDF]

, 2013
A 61-year-old gentleman who lives with his wife and 20-year-old son, presented to the polyclinic with a four week history of pruritus. On examination he was found to be jaundiced and his LFTs were high.
Bezzina, Sarah, Debattista, Daniel
core  

Conformation Dependent Room Temperature Phosphorescence in Organic Materials

ChemPhotoChem, EarlyView.
Room temperature phosphorescence from organic materials in the solid state can be tuned owing to changes in the molecular arrangement occurring in crystalline and amorphous phases. This review presents recent results that discuss conformation dependent triplet emission, revealing its role in the design of organic functional materials with diverse ...
Andrea Fermi
wiley   +1 more source