Results 1 to 10 of about 29 (23)

Design, synthesis and potential biological activities of 1,2,3-triazole-diazaphenothiazine hybrids containing diquinothiazine units

2020
Fischer, Katarzyna, Grabka, Kamil
openaire  

Synthesis and structures of new diquinothiazines

2013
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New diquinothiazines and quinonaphthothiazines - syntheses and structures

2014
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14-Substituted Diquinothiazines as a New Group of Anticancer Agents [PDF]

Molecules, 2023
A series of novel double-angularly condensed diquinothiazines with aminoalkyl, amidoalkyl, sulfonamidoalkyl, and substituted phenyl groups was designed, synthesized, and evaluated for their anticancer activity against four selected human tumor cell lines
Małgorzata Jeleń, Krystian Pluta, Małgorzata Szmielew, Beata Morak-Młodawska, Kinga Herman, Klaudia Giercuszkiewicz, Anna Kasprzycka, Magdalena Skonieczna   +7 more
doaj   +4 more sources

Study of the Lipophilicity and ADMET Parameters of New Anticancer Diquinothiazines with Pharmacophore Substituents [PDF]

Pharmaceuticals
Lipophilicity is one of the principal parameters that describe the pharmacokinetic behavior of a drug, including its absorption, distribution, metabolism, elimination, and toxicity.
Daria Klimoszek, Małgorzata Jeleń, Małgorzata Dołowy, Beata Morak-Młodawska   +3 more
doaj   +5 more sources

Evaluation of the Lipophilicity of Angularly Condensed Diquino- and Quinonaphthothiazines as Potential Candidates for New Drugs [PDF]

Molecules
Lipophilicity is one of the most important properties of compounds required to estimate the absorption, distribution, and transport in biological systems, in addition to solubility, stability, and acid–base nature.
Daria Klimoszek, Małgorzata Jeleń, Beata Morak-Młodawska, Małgorzata Dołowy   +3 more
doaj   +2 more sources

6-[3-(p-Tolyl-sulfonyl-amino)-prop-yl]diquino-thia-zine. [PDF]

Acta Crystallogr Sect E Struct Rep Online, 2013
In the title mol-ecule {systematic name: N-[3-(diquino[3,2-b;2',3'-e][1,4]thia-zin-6-yl)prop-yl]-4-methyl-benzene-sulfon-amide}, C28H24N4O2S2, the penta-cyclic system is relatively planar [maximum deviation from the mean plane = 0.242 (1) Å]. The dihedral angle between two quinoline ring systems is 8.23 (2)° and that between the two halves of the 1,4 ...
Jeleń M, Shkurenko A, Suwińska K, Pluta K, Morak-Młodawska B.   +4 more
europepmc   +4 more sources

Evaluation of angularly condensed diquinothiazines as potential anticancer agents

Bioorganic Chemistry, 2019
We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2'-dichloro-3,3'-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines. The pentacyclic diquinothiazine ring systems were identified as diquino[3,2-b;3',4'-e][1,4]thiazine, diquino[3,2-b;5',6'-e][1,4]thiazine, diquino[3,2-
Jeleń M., Pluta K., Latocha M., Morak-Młodawska B., Suwińska K., Kuśmierz D.   +5 more
openaire   +4 more sources

In vitro study of antioxidant, antigylycation, sugar hydrolysis enzyme inhibitory effect and molecular in silico docking study of angularly condensed diquinothiazines

Journal of Molecular Structure
Angularly condensed diquinothiazines (MY1, MY2, and MY3) a phenothiazine derivative was evaluated for antioxidant, antiglycation, sugar hydrolysis enzyme inhibitory effect and molecular in silico docking. Antioxidants were evaluated using DPPH, chelating ion, FRAP and lipid peroxidation. Alpha glucosidase and alpha amylase inhibition was used for sugar
Małgorzata Jeleń, Pheony Ting Chin Ying, Yanling Hao, Abbirami Balachandran, Kirthani Anamalay, Beata Morak‐Młodawska, Anand Gaurav, Charlie A. Lavilla, Mylene M. Uy, Merell P. Billacura, Patrick Nwabueze Okechukwu   +10 more
openaire   +1 more source

Tri- and Pentacyclic Azaphenothiazine as Pro-Apoptotic Agents in Lung Carcinoma with a Protective Potential to Healthy Cell Lines. [PDF]

Molecules, 2022
Skonieczna M, Kasprzycka A, Jeleń M, Morak-Młodawska B.   +3 more
europepmc   +1 more source