Results 1 to 10 of about 6,613 (146)
Phenothiazines enhance antibacterial activity of macrophage by inducing ROS and autophagy [PDF]
Frontiers in ImmunologyBacterial infections pose a major global public health threat. While antibiotics have historically served as the primary treatment, the rapid rise of antibiotic resistance has led to an urgent need for new therapeutic strategies. Host-directed therapies (
Lihao Qiu +5 more
doaj +2 more sources
Antibiotics, 2013 Phenothiazines have their primary effects on the plasma membranes of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources and energy providing enzymes, such as ATPase, and ...
Jette E Kristiansen +2 more
exaly +3 more sources
Mechanochemical Dehydrogenative Phenochalcogenazination: A Pronounced Water Effect [PDF]
ChemSusChem, Volume 19, Issue 12, 26 June 2026.We report herein the first organic solvent‐free mechanochemical dehydrogenative phenochalcogenazination reaction, with a persulfate salt as a terminal oxidant and wetted silica as a crucial additive. A mechanochemical phenochalcogenazination (X = O, S, Se) of phenols and related compounds in the ball mill is reported.
Alina Paffen +5 more
wiley +2 more sources
Life, 2021 Small molecules are routinely used to inhibit protein kinases, but modulators capable of enhancing kinase activity are rare. We have previously shown that the small molecule INR119, designed as an inhibitor of MEK1/2, will enhance the activity of its ...
Michał Otręba +3 more
doaj +1 more source
Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
doaj +1 more source
Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
doaj +1 more source
Antibiotics, 2022 Persistent apical periodontitis occurs when the endodontic treatment fails to eradicate the intraradicular infection, and is mainly caused by Gram-positive bacteria and yeasts, such as Enterococcus faecalis and Candida albicans, respectively ...
Nicole de Mello Fiallos +7 more
doaj +1 more source
Molecules, 2021 Phenothiazines are known as synthetic antipsychotic drugs that exhibit a wide range of biological effects. Their properties result from the structure and variability of substituents in the heterocyclic system.
Andrzej Poła +2 more
doaj +1 more source
Chemosensors, 2022 Array-based optical sensing is an efficient technique for the determination and discrimination of small organic molecules. This study is aimed at the development of a simple and rapid strategy for obtaining an optical response from a wide range of low ...
Anna V. Shik +4 more
doaj +1 more source
Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in Escherichia coli
Toxins, 2021 Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties.
John K. Crane +2 more
doaj +1 more source