Effect of Thioridazine on Erythrocytes [PDF]
Toxins, 2013 Background: Thioridazine, a neuroleptic phenothiazine with antimicrobial efficacy is known to trigger anemia. At least in theory, the anemia could result from stimulation of suicidal erythrocyte death or eryptosis, which is characterized by cell ...
Caterina Faggio +2 more
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Repurposing thioridazine as a potential CD2068 inhibitor to mitigate antibiotic resistance in Clostridioides difficile infection [PDF]
Computational and Structural Biotechnology JournalClostridioides difficile infection (CDI) is a major public health issue, driven by antibiotic resistance and frequent recurrence. CD2068, an ABC protein in C. difficile, is associated with drug resistance, making it a potential target for novel therapies.
Methinee Pipatthana +10 more
doaj +2 more sources
Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy [PDF]
Animal Cells and SystemsYes-associated protein (YAP), a key co-transcription factor of the Hippo pathway, is a promising drug target for cancer therapy due to its critical role in promoting cell proliferation, survival, and tumor progression when dysregulated.
Ji-Youn Lim +6 more
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Impact of Early Antipsychotic Prescription Choice on Weight Gain in the First 5 Years of Psychotic Illness: a Retrospective Cohort Study [PDF]
Neurology and TherapyIntroduction We analysed the effects of antipsychotic drug prescribing in year 1 of treatment for psychosis on future weight gain over 5 years. Methods We studied how weight changed over 5 years after the first diagnosis of psychosis/schizophrenia ...
Adrian Heald +11 more
doaj +2 more sources
Synergistic Photothermal-Chemotherapy of Hepatocellular Carcinoma and Cancer Stem Cells via in situ pH-Responsive Hydrogels [PDF]
International Journal of NanomedicineYunchao Wu,1,* Xin Xu,1,* Zhen Zhu,1 Fengyi Du,2 Guojun Zheng1 1Central Laboratory, The Affiliated Changzhou Hospital of Xuzhou Medical University, Changzhou Third People’s Hospital, Changzhou, Jiangsu, 213000, People’s Republic of China;
Wu Y, Xu X, Zhu Z, Du F, Zheng G
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Molecular mechanisms of thioridazine resistance in Staphylococcus aureus. [PDF]
PLoS ONE, 2018 Staphylococcus aureus has developed resistance towards the most commonly used anti-staphylococcal antibiotics. Therefore, there is an urgent need to find new treatment opportunities. A new approach relies on the use of helper compounds, which are able to
Claes Søndergaard Wassmann +6 more
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Chinese Journal of Physiology, 2020 Thioridazine, belonging to first-generation antipsychotic drugs, is a prescription used to treat schizophrenia. However, the effect of thioridazine on intracellular Ca2+ concentration ([Ca2+]i) and viability in human liver cancer cells is unclear.
I-Shu Chen +6 more
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Thioridazine for schizophrenia [PDF]
Cochrane Database of Systematic Reviews, 2000 Thioridazine is a piperidine phenothiazine used for the treatment of people with schizophrenia. It has often been considered the drug of choice in the elderly because of reputed lower levels of extrapyramidal adverse events. It may, however, be more likely to cause cognitive adverse events, such as delirium or worsening of memory, and, on rare ...
Fenton, M. +3 more
openaire +4 more sources
A comparative analysis of in vitro and in vivo efficacies of the enantiomers of thioridazine and its racemate. [PDF]
PLoS ONE, 2013 A long list of chemotherapeutical drugs used in the treatment of the peripheral and the central nervous systems possess anti-microbial activity. Some of these neurotropic compounds are chiral, with the one stereo isomeric form exaggerating reduced ...
Jørn B Christensen +7 more
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Synthesis of the Enantiomers of Thioridazine
SynOpen, 2020 Thioridazine, a well-known antipsychotic drug, has shown promising effects on several bacterial strains (including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus).
Simen Antonsen +7 more
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