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Effect of Thioridazine on Erythrocytes [PDF]
Toxins, 2013 Background: Thioridazine, a neuroleptic phenothiazine with antimicrobial efficacy is known to trigger anemia. At least in theory, the anemia could result from stimulation of suicidal erythrocyte death or eryptosis, which is characterized by cell ...
Majed Abed +6 more
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Thioridazine for schizophrenia [PDF]
Cochrane Database of Systematic Reviews, 2000 Thioridazine is a piperidine phenothiazine used for the treatment of people with schizophrenia. It has often been considered the drug of choice in the elderly because of reputed lower levels of extrapyramidal adverse events. It may, however, be more likely to cause cognitive adverse events, such as delirium or worsening of memory, and, on rare ...
Fenton, M. +3 more
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Synthesis of the Enantiomers of Thioridazine [PDF]
SynOpen, 2020 Thioridazine, a well-known antipsychotic drug, has shown promising effects on several bacterial strains (including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus).
Simen Antonsen +7 more
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Molecular mechanisms of thioridazine resistance in Staphylococcus aureus. [PDF]
PLoS ONE, 2018 Staphylococcus aureus has developed resistance towards the most commonly used anti-staphylococcal antibiotics. Therefore, there is an urgent need to find new treatment opportunities. A new approach relies on the use of helper compounds, which are able to
Claes Søndergaard Wassmann +6 more
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Chinese Journal of Physiology, 2020 Thioridazine, belonging to first-generation antipsychotic drugs, is a prescription used to treat schizophrenia. However, the effect of thioridazine on intracellular Ca2+ concentration ([Ca2+]i) and viability in human liver cancer cells is unclear.
I-Shu Chen +6 more
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A comparative analysis of in vitro and in vivo efficacies of the enantiomers of thioridazine and its racemate. [PDF]
PLoS ONE, 2013 A long list of chemotherapeutical drugs used in the treatment of the peripheral and the central nervous systems possess anti-microbial activity. Some of these neurotropic compounds are chiral, with the one stereo isomeric form exaggerating reduced ...
Jørn B Christensen +7 more
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Journal of Infection in Developing Countries, 2023 Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii +7 more
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The Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Rats
Psychiatry and Clinical Psychopharmacology, 2021 Objective: The effects of antipsychotic drugs, of whose different classes can be used in the treatment of patients with resistant to schizophrenia, on the fetus and the benefits of the treatment to the mother should be taken into consideration before ...
Cagatay Oltulu, Cetin Hakan Karadag
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Life, 2021 Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the ...
Carina Colturato-Kido +6 more
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Redox Biology, 2017 Thioridazine is known to have anti-tumor effects by inhibiting PI3K/Akt signaling, which is an important signaling pathway in cell survival. However, thioridazine alone does not induce apoptosis in head and neck squamous cell carcinoma (AMC-HN4), human ...
Seung Un Seo +4 more
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