Results 21 to 30 of about 6,461 (151)

Antibacterial properties of thioridazine

open access: yesФармацевтичний журнал, 2019
The emergence and spread of antibiotic-resistant strains of microorganisms reduces the effectiveness of antibiotic therapy and requires finding solutions to problems, one of which is the study of antimicrobial properties in drugs of various ...
N. Hrynchuk, N. Vrynchanu
doaj   +1 more source

Thioridazine for dementia

open access: yesCochrane Database of Systematic Reviews, 2001
Neuroleptic drugs are controversial treatments in dementia, with evidence accumulating that they may hasten clinical decline. Despite these concerns, they are commonly prescribed for elderly and demented patients. Thioridazine, a phenothiazine neuroleptic, has been commonly prescribed because it was thought to produce relatively less frequent motor ...
V, Kirchner, A, Kelly C, R J, Harvey
openaire   +4 more sources

Descemet's stripping-automated endothelial keratoplasty for symptomatic thioridazine deposits in the cornea

open access: yesTaiwan Journal of Ophthalmology, 2017
The aim of this study was to use Descemet's Stripping-automated Endothelial Keratoplasty (DSAEK) as a novel treatment to remove thioridazine corneal deposits. A 53-year-old female presented with a 3-month history of visual loss and glare.
Masoumeh Mohebbi   +3 more
doaj   +1 more source

Tentative susceptibility testing breakpoint for the neuroleptic drug thioridazine, a treatment option for multi- and extensively drug resistant tuberculosis

open access: yesInternational Journal of Mycobacteriology, 2012
Introduction: New drugs against multi-(MDR) and extensively drug (XDR) resistant tuberculosis are urgently needed. While new candidate drugs are being developed, reinvestigation of already approved drugs available for other indications could be of value.
Kristian Angeby   +3 more
doaj   +1 more source

Acute and Subchronic Toxic Effects of Thioridazine versus Pimozide on Liver, Kidney and Heart of Adult Male Albino Rats: Biochemical and Histological Study [PDF]

open access: yesAin Shams Journal of Forensic Medicine and Clinical Toxicology, 2013
Antipsychotic drugs are potent drugs that therapeutically modify behavior. They are widely used all over the world. This study was planned to compare the biochemical and histological alterations induced by acute and subchronic toxic effects of the ...
Noha Afifi, Amany Mohammed
doaj   +1 more source

Coprescription of QT interval-prolonging antipsychotics with potentially interacting medications in Thailand

open access: yesTherapeutic Advances in Drug Safety, 2019
Background: The US FDA has designated pimozide, thioridazine, and ziprasidone as contraindicated for patients at risk of QT interval prolongation, and assigned haloperidol, olanzapine, paliperidone, quetiapine, and risperidone as associated with a ...
Onanong Waleekhachonloet   +2 more
doaj   +1 more source

Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action

open access: yesAntibiotics, 2017
This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of a pulmonary tuberculosis infection regardless of its antibiotic resistance status.
Leonard Amaral, Miguel Viveiros
doaj   +1 more source

Synthesis and Characterization of pH-Responsive PEG-Poly(β-Amino Ester) Block Copolymer Micelles as Drug Carriers to Eliminate Cancer Stem Cells

open access: yesPharmaceutics, 2020
PEG-poly(β-amino ester) (PEG-PBAE), which is an effective pH-responsive copolymer, was mainly synthesized by Michael step polymerization. Thioridazine (Thz), which was reported to selectively eliminate cancer stem cells (CSCs), was loaded into PEG ...
Weinan Li   +8 more
doaj   +1 more source

Thioridazine Sensitizes Apoptotic Effect of TRAIL in Human Lung Cancer PC9 Cells Through ER Stress Mediated Up-regulation of DR5

open access: yesChinese Journal of Lung Cancer, 2017
Background and objective Tumor necrosis factor-related apoptosis-inducting ligand (TRAIL) can induce apoptosis of tumor cells, however, various of tumor cells may survive because of resistance to TRAIL-mediated apoptosis.
Juan LI   +4 more
doaj   +1 more source

The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis.

open access: yesPLoS ONE, 2010
Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon.
Dick van Soolingen   +7 more
doaj   +1 more source

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