Results 11 to 20 of about 7,819 (191)

Thioridazine for dementia

Cochrane Database of Systematic Reviews, 2001
Neuroleptic drugs are controversial treatments in dementia, with evidence accumulating that they may hasten clinical decline. Despite these concerns, they are commonly prescribed for elderly and demented patients. Thioridazine, a phenothiazine neuroleptic, has been commonly prescribed because it was thought to produce relatively less frequent motor ...
V, Kirchner, A, Kelly C, R J, Harvey
openaire   +5 more sources

The effects of thioridazine on the QTc interval - cardiovascular safety in a South African setting

South African Journal of Psychiatry, 2005
Background. Thioridazine has long been used as a first-line antipsychotic in South Africa without any apparent problems. Recently the American Food and Drug Administration (FDA) and Novartis have warned of potentially lethal arrhythmias that may result ...
Cathlene Seller, Piet Oosthuizen
doaj   +4 more sources

Mechanism of Killing Effect of Thioridazine on Human Lung Cancer PC9 Cells

Chinese Journal of Lung Cancer, 2015
Background and objective Recent research shows thioridazine which is a kind of phenothiazine antipsychotic drugs can inhibit the proliferation of various tumor cells in vitro, but the role of thioridazine on lung cancer has not been reported.
Li GONG, Yi WANG, Sihao TONG, Liu LIU, Ling NIU, Yuan YUAN, Yangyi BAO   +6 more
doaj   +2 more sources

Fluorinated covalent organic framework hydrogel reprograms Piezo1/YAP mechanotransduction for sustained prevention of peritendinous adhesion [PDF]

Bioactive Materials
Postoperative peritendinous adhesion arises from sustained fibroblast activity, collagen overproduction, and dysregulated mechanical signaling during tendon repair; however, few current treatments can deliver a prolonged molecular intervention across the
Baoyiyu Xu, Jinlan Luo, Sa Pang, Chengchao Tu, Jiacheng Hu, Junjie Zhao, Tianyi Zhang, Pusheng Guo, Wei Zheng, Yuan Wang, Wengang Li, Yi Wang, Shen Liu   +12 more
doaj   +2 more sources

Pharmacotherapeutic Management of Depression in Patients With Cancer: A Review of Mechanistic and Clinical Evidence [PDF]

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Depression is a prevalent comorbidity in cancer, yet conventional treatments show inconsistent efficacy. This review sought to provide a mechanism‐based framework for managing cancer‐related depression by exploring its unique pathophysiology and evaluating promising pharmacotherapies based on their alignment with these biological ...
Sepideh Hajivalizadeh, Kimia Farahmand, Kimia Kazemzadeh, Ghazaleh Hajivalizadeh, Ahmad Shamabadi   +4 more
wiley   +2 more sources

Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy [PDF]

Animal Cells and Systems
Yes-associated protein (YAP), a key co-transcription factor of the Hippo pathway, is a promising drug target for cancer therapy due to its critical role in promoting cell proliferation, survival, and tumor progression when dysregulated.
Ji-Youn Lim, Eui-Hwan Choi, Yujeong Kim, Minseong Kim, Dongkyu Choi, Wantae Kim, Boksik Cha   +6 more
doaj   +2 more sources

Repurposing thioridazine as a potential CD2068 inhibitor to mitigate antibiotic resistance in Clostridioides difficile infection [PDF]

Computational and Structural Biotechnology Journal
Clostridioides difficile infection (CDI) is a major public health issue, driven by antibiotic resistance and frequent recurrence. CD2068, an ABC protein in C. difficile, is associated with drug resistance, making it a potential target for novel therapies.
Methinee Pipatthana, Matthew Phanchana, Apiwat Sangphukieo, Sitthivut Charoensutthivarakul, Phurt Harnvoravongchai, Surang Chankhamhaengdecha, Pattaneeya Prangthip, Pattanai Konpetch, Chanakarn Sripong, Sarawut Wongphayak, Tavan Janvilisri   +10 more
doaj   +2 more sources

Trial of Methylphenidate and Thioridazine

Pediatric Neurology Briefs, 1991
A double-blind, placebo-controlled, cross-over study of methylphenidate (0.4 mg/kg/day) and thioridazine (1.75 mg/kg/day) in 27 intellectually subaverage children is reported from The Nisonger Center for Mental Retardation and Developmental Disabilities,
J Gordon Millichap
doaj   +2 more sources

Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy

International Journal of Nanomedicine, 2016
Xun Jin,1,* Bingwen Zou,2,* Li Luo,1,* Chuanhong Zhong,3 Peilan Zhang,1 Hao Cheng,1 Yanfang Guo,1 Maling Gou1 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for ...
Jin X, Zou B, Luo L, Zhong C, Zhang P, Cheng H, Guo Y, Gou M   +7 more
doaj   +1 more source

Impact of Early Antipsychotic Prescription Choice on Weight Gain in the First 5 Years of Psychotic Illness: a Retrospective Cohort Study [PDF]

Neurology and Therapy
Introduction We analysed the effects of antipsychotic drug prescribing in year 1 of treatment for psychosis on future weight gain over 5 years. Methods We studied how weight changed over 5 years after the first diagnosis of psychosis/schizophrenia ...
Adrian Heald, George Tilston, John Julian Warner-Levy, Loren Wilkins, Richard Williams, Toby Pillinger, William Deakin, Damien Longson, Lamiece Hassan, Caroline Dalton, Gavin P. Reynolds, Joseph Firth   +11 more
doaj   +2 more sources