Results 11 to 20 of about 6,461 (151)

Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

open access: yesJournal of Infection in Developing Countries, 2023
Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii   +7 more
doaj   +1 more source

The Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Rats

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
Objective: The effects of antipsychotic drugs, of whose different classes can be used in the treatment of patients with resistant to schizophrenia, on the fetus and the benefits of the treatment to the mother should be taken into consideration before ...
Cagatay Oltulu, Cetin Hakan Karadag
doaj   +1 more source

Inhibition of Autophagy Enhances the Antitumor Effect of Thioridazine in Acute Lymphoblastic Leukemia Cells

open access: yesLife, 2021
Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the ...
Carina Colturato-Kido   +6 more
doaj   +1 more source

NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin

open access: yesRedox Biology, 2017
Thioridazine is known to have anti-tumor effects by inhibiting PI3K/Akt signaling, which is an important signaling pathway in cell survival. However, thioridazine alone does not induce apoptosis in head and neck squamous cell carcinoma (AMC-HN4), human ...
Seung Un Seo   +4 more
doaj   +1 more source

Type IV Pilus-Mediated Inhibition of Acinetobacter baumannii Biofilm Formation by Phenothiazine Compounds

open access: yesMicrobiology Spectrum, 2023
Infections by pathogenic Acinetobacter species represent a significant burden on the health care system, despite their relative rarity, due to the difficulty of treating infections through oral antibiotics.
Nam Vo   +3 more
doaj   +1 more source

The effects of thioridazine on the QTc interval - cardiovascular safety in a South African setting

open access: yesSouth African Journal of Psychiatry, 2005
Background. Thioridazine has long been used as a first-line antipsychotic in South Africa without any apparent problems. Recently the American Food and Drug Administration (FDA) and Novartis have warned of potentially lethal arrhythmias that may result ...
Cathlene Seller, Piet Oosthuizen
doaj   +1 more source

A Novel Derivative of Thioridazine Shows Low Toxicity and Efficient Activity against Gram-Positive Pathogens

open access: yesAntibiotics, 2020
Thioridazine hydrochloride (HCl) has been suggested as a promising antimicrobial helper compound for the treatment of infections with antimicrobial-resistant bacteria.
Nadia S. Jørgensen   +9 more
doaj   +1 more source

Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumps

open access: yesJournal of Global Antimicrobial Resistance, 2022
: Objectives: Mycobacterium abscessus is an opportunistic respiratory pathogen in patients with underlying lung disease. It is infamously known for its low treatment success rates because of its resistance to multiple classes of antibiotics.
Saskia E. Mudde   +6 more
doaj   +1 more source

Mechanism of Killing Effect of Thioridazine on Human Lung Cancer PC9 Cells

open access: yesChinese Journal of Lung Cancer, 2015
Background and objective Recent research shows thioridazine which is a kind of phenothiazine antipsychotic drugs can inhibit the proliferation of various tumor cells in vitro, but the role of thioridazine on lung cancer has not been reported.
Li GONG   +6 more
doaj   +1 more source

A Carbon Nanocomposite Ionic Liquid Electrode Based on Montmorillonite Nanoclay for Sensitive Voltammetric Determination of Thioridazine

open access: yesInternational Journal of Electrochemical Science, 2014
A carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode for the electrochemical determination of (10-[2-(1-methyl-2- piperidyl) ethyl]-2-methylthiophenothiazine) (thioridazine)
P.Aberoomand Azar   +3 more
doaj   +1 more source

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