Results 41 to 50 of about 7,819 (191)
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Thioridazine Levels in the Human Eye
, 1981 Thioridazine (Mellaril) hydrochloride was found in human retina and choroid by high-performance liquid chromatography. To our knowledge, this report is the first such study to assess quantitatively the presence of thioridazine in the human eye.
B. O. Kimbrough +3 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
Pregnancy, Volume 2, Issue 6, November 2026.Abstract Substance use complicates upward of 10% of US pregnancies. The Society for Maternal‐Fetal Medicine, the American College of Obstetricians and Gynecologists, and the American Society of Addiction Medicine have jointly recommended universal screening for substance use during pregnancy using a validated tool, without recommending universal ...
Society for Maternal‐Fetal Medicine (SMFM) +8 more
wiley +1 more source
Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient
Pharmaceuticals, 2012 This mini-review provides the entire experimental history of the development of the old neuroleptic thioridazine (TZ) for therapy of antibiotic resistant pulmonary tuberculosis infections.
Joseph Molnar, Leonard Amaral
doaj +1 more source
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide [PDF]
, 2022 Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14–15 months after surgery, radiation and chemotherapy using temozolomide (TMZ). A major problem is that the tumors acquire resistance to therapy.
Morten Lund‐Johansen +19 more
core +1 more source
Acta Ophthalmologica, Volume 104, Issue 6, Page e630-e647, September 2026.Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen +3 more
wiley +1 more source
Targeting Ca2+ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells
Life, 2022 Mitochondria have pivotal roles in cellular physiology including energy metabolism, reactive oxygen species production, Ca2+ homeostasis, and apoptosis. Altered mitochondrial morphology and function is a common feature of cancer cells and the regulation ...
Vivian W. R. Moraes +12 more
doaj +1 more source
MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Cancer Science, Volume 117, Issue 8, Page 2050-2063, August 2026.Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
wiley +1 more source
Pharmaceutics, 2022 5-fluorouracil (5-FU) and doxorubicin (DOX) are potent anti-tumour agents commonly used for colon and breast cancer therapy, respectively. However, their clinical application is limited by their side effects and the development of drug resistance ...
Diana Duarte +4 more
doaj +1 more source