Results 31 to 40 of about 7,819 (191)

Three Component Thio‐ and Carboboration of Alkynes: A Modular Route to Functionalised Bicyclic Boronates

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Three‐component thio‐ and carbo‐boration reactions to form functionalised benzoxaborinines and benzazaborinines are reported. The nucleophile scope includes thioethers, thiols, and (hetero)arenes. Mechanistic studies revealed a disparity between thioboration using thioethers and using thiols.
Laura Winfrey, Gary S. Nichol, Stephen P. Thomas, Dominic R. Willcox, Michael. J. Ingleson   +4 more
wiley   +2 more sources

Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action

Antibiotics, 2017
This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of a pulmonary tuberculosis infection regardless of its antibiotic resistance status.
Leonard Amaral, Miguel Viveiros
doaj   +1 more source

Thioridazine Sensitizes Apoptotic Effect of TRAIL in Human Lung Cancer PC9 Cells Through ER Stress Mediated Up-regulation of DR5

Chinese Journal of Lung Cancer, 2017
Background and objective Tumor necrosis factor-related apoptosis-inducting ligand (TRAIL) can induce apoptosis of tumor cells, however, various of tumor cells may survive because of resistance to TRAIL-mediated apoptosis.
Juan LI, Yi WANG, Liu LIU, Yuan YUAN, Yangyi BAO   +4 more
doaj   +1 more source

Coprescription of QT interval-prolonging antipsychotics with potentially interacting medications in Thailand

Therapeutic Advances in Drug Safety, 2019
Background: The US FDA has designated pimozide, thioridazine, and ziprasidone as contraindicated for patients at risk of QT interval prolongation, and assigned haloperidol, olanzapine, paliperidone, quetiapine, and risperidone as associated with a ...
Onanong Waleekhachonloet, Chulaporn Limwattananon, Thananan Rattanachotphanit   +2 more
doaj   +1 more source

The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis.

PLoS ONE, 2010
Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon.
Dick van Soolingen, Rogelio Hernandez-Pando, Hector Orozco, Diana Aguilar, Cecile Magis-Escurra, Leonard Amaral, Jakko van Ingen, Martin J Boeree   +7 more
doaj   +1 more source

Synthesis and Characterization of pH-Responsive PEG-Poly(β-Amino Ester) Block Copolymer Micelles as Drug Carriers to Eliminate Cancer Stem Cells

Pharmaceutics, 2020
PEG-poly(β-amino ester) (PEG-PBAE), which is an effective pH-responsive copolymer, was mainly synthesized by Michael step polymerization. Thioridazine (Thz), which was reported to selectively eliminate cancer stem cells (CSCs), was loaded into PEG ...
Weinan Li, Jialin Sun, Xiaoyu Zhang, Li Jia, Mingxi Qiao, Xiuli Zhao, Haiyang Hu, Dawei Chen, Yanhong Wang   +8 more
doaj   +1 more source

Acute and Subchronic Toxic Effects of Thioridazine versus Pimozide on Liver, Kidney and Heart of Adult Male Albino Rats: Biochemical and Histological Study [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2013
Antipsychotic drugs are potent drugs that therapeutically modify behavior. They are widely used all over the world. This study was planned to compare the biochemical and histological alterations induced by acute and subchronic toxic effects of the ...
Noha Afifi, Amany Mohammed
doaj   +1 more source

Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials

Antibiotics, 2020
Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants
Carla C. C. R. de Carvalho, Raquel Teixeira, Pedro Fernandes   +2 more
doaj   +1 more source

Lamotrigine-Induced Acute Hepatic Failure

Pediatric Neurology Briefs, 1998
An 8-year-old boy with seizures who developed acute hepatic failure during treatment with lamotrigine is reported from the Department of Pediatrics, Columbia University, New York.
J Gordon Millichap
doaj   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source