Results 31 to 40 of about 6,461 (151)

Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials

Antibiotics, 2020
Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants
Carla C. C. R. de Carvalho, Raquel Teixeira, Pedro Fernandes   +2 more
doaj   +1 more source

Lamotrigine-Induced Acute Hepatic Failure

Pediatric Neurology Briefs, 1998
An 8-year-old boy with seizures who developed acute hepatic failure during treatment with lamotrigine is reported from the Department of Pediatrics, Columbia University, New York.
J Gordon Millichap
doaj   +1 more source

Honeybee Venom Synergistically Enhances the Cytotoxic Effect of CNS Drugs in HT-29 Colon and MCF-7 Breast Cancer Cell Lines

Pharmaceutics, 2022
5-fluorouracil (5-FU) and doxorubicin (DOX) are potent anti-tumour agents commonly used for colon and breast cancer therapy, respectively. However, their clinical application is limited by their side effects and the development of drug resistance ...
Diana Duarte, Soraia I. Falcão, Iouraouine El Mehdi, Miguel Vilas-Boas, Nuno Vale   +4 more
doaj   +1 more source

Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient

Pharmaceuticals, 2012
This mini-review provides the entire experimental history of the development of the old neuroleptic thioridazine (TZ) for therapy of antibiotic resistant pulmonary tuberculosis infections.
Joseph Molnar, Leonard Amaral
doaj   +1 more source

Targeting Ca²⁺ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells

Life, 2022
Mitochondria have pivotal roles in cellular physiology including energy metabolism, reactive oxygen species production, Ca2+ homeostasis, and apoptosis. Altered mitochondrial morphology and function is a common feature of cancer cells and the regulation ...
Vivian W. R. Moraes, Vivian M. Santos, Eloah R. Suarez, Letícia S. Ferraz, Rayssa de Mello Lopes, Giuliana P. Mognol, Joana D. Campeiro, João A. Machado-Neto, Fabio D. Nascimento, Mirian A. F. Hayashi, Ivarne L. S. Tersariol, Donald D. Newmeyer, Tiago Rodrigues   +12 more
doaj   +1 more source

Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance

Neurobiology of Disease, 2021
Brain inclusions mainly composed of misfolded and aggregated TAR DNA binding protein 43 (TDP-43), are characteristic hallmarks of amyotrophic lateral sclerosis (ALS).
Lucia Cragnaz, Greta Spinelli, Laura De Conti, Emilie A. Bureau, Janet Brownlees, Fabian Feiguin, Valentina Romano, Natasa Skoko, Raffaella Klima, Catherine A. Kettleborough, Francisco E. Baralle, Marco Baralle   +11 more
doaj   +1 more source

Sweet syndrome-like cutaneous drug reaction [PDF]

Anais Brasileiros de Dermatologia, 2017
: Cutaneous drug reactions are adverse reactions to medications that may present with different clinical features, ranging from localized to generalized lesions.
Lissandra Melati da Silva, Raquel de Almeida Boechat, Iale Oliveira da Hora, José Roberto Pereira Pegas   +3 more
doaj   +2 more sources

The availability of essential medicines for mental healthcare in Sofala, Mozambique [PDF]

Global Health Action, 2015
Objective: We assessed the availability of essential medicines for mental healthcare (MH) across levels of the public healthcare system to aid in future systems planning. Design: Non-expired MH medications were assessed in 24 public health facilities and
Bradley H. Wagenaar, Andy Stergachis, Deepa Rao, Roxanne Hoek, Vasco Cumbe, Manuel Napúa, Kenneth Sherr   +6 more
doaj   +1 more source

Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination

International Journal of Electrochemical Science, 2017
A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed.
B.B. Petković, D. Kuzmanović, T. Dimitrijević, M.P. Krstić, D.M. Stanković   +4 more
doaj   +1 more source

Synergistic antibacterial effects of 5-fluorouracil or thioridazine in combination with phytopolyphenols on cultured Porphyromonas gingivalis

Journal of Dental Sciences, 2023
Background/purpose: 5-Fluorouracil (5FU) is a commonly used anticancer drug. However, the severe oral mucositis induced by 5FU in about 60–70% of patients was a major cause of discontinuous therapy. Since oral dysbiosis induced by 5FU was well correlated
Yu-Feng Huang, Hui-Wen Yang, Shoei-Yn Lin-Shiau   +2 more
doaj   +1 more source