Results 61 to 70 of about 7,819 (191)

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

Differential effects of thioridazine enantiomers on action potential duration in rabbit papillary muscle

, 2015
The antipsychotic drug thioridazine has potential for treatment of multidrug-resistant microbes including tuberculosis but also causes cardiotoxic QT interval prolongation.
Jensen, A. S., Sevcencu, C., Kristiansen, J. E., Kristiansen, Jette Elisabeth, Jensen, Ask Schou, Christensen, J. B., Sevcencu, Cristian, Struijk, Johannes Jan, Pennisi, Cristian Pablo, Pennisi, C. P., Christensen, Jørn Bolstad, Struijk, Johannes; id_orcid, Struijk, J. J., Pennisi, Cristian Pablo; id_orcid   +13 more
core   +1 more source

Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia

Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.
Peroxisomes are emerging as key regulators of lipid metabolism in leukemia. Enhanced metabolism of very‐long‐chain fatty acids (VLCFAs) supports leukemia cell survival, redox homeostasis, and therapeutic resistance. Pharmacologic disruption of peroxisomal fatty acid oxidation causes VLCFA accumulation, oxidative stress, and mitochondrial dysfunction ...
Ekaterina N. Parfenova, Paul A. Spagnuolo   +1 more
wiley   +1 more source

Trajectories of Treatment Disruption for Chronic Outpatient Medications for U.S. Veterans During Drug Shortages

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Introduction Although drug shortages for outpatient chronic conditions commonly occur, population‐level data on how they impact patients' ability to refill prescriptions is scarce. We sought to identify distinct patterns of refill adherence following drug shortages and patient‐ and prescription‐level factors associated with adherence ...
Katie J. Suda, Xinhua Zhao, Sherrie L. Aspinall, Yaming Li, Katherine Callaway Kim, Francesca E. Cunningham, Taylor L. Boyer, Tate W. Miner, Clara Kima, Walid F. Gellad, Peter A. Glassman, Chester B. Good, Felicia Skelton, Mina Tadrous, Carolyn T. Thorpe   +14 more
wiley   +1 more source

THE EFFECTS OF NEUROLEPTICS AND DILTIAZEM ON EXPERIMENTAL SCHIZOPHRENIA MODEL INDUCED BY PHENYLETHYLAMINE

Psychiatry and Clinical Psychopharmacology, 2021
Objective: The effects of typical and atypical neuroleptics were determined in wistar rats in which experimental schizophrenia model was formed by using phenylethylamine (PEA) and these effects were compared with the effects of calcium channel blocker ...
Z. Nur Banoğlu, Serpil Karayaka
doaj  

DNA damage response and repair data with pharmacological modulators of Tousled

Data in Brief, 2016
Human Tousled kinase 1 (TLK1) plays an important role in chromatin remodeling, replication, and DNA damage response and repair. TLK1 activity is immediately, but transiently, downregulated after genotoxic insult, and its recovery is important for exit ...
Prakash Srinivasan Timiri Shanmugam, Renjith P. Nair, Arrigo DeBenedetti, Gloria Caldito, Fleurette Abreo, Gulshan Sunavala-Dossabhoy   +5 more
doaj   +1 more source

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

Physiological Reports, 2020
The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG‐encoded channels responsible for the rapid delayed rectifier K+ current I(Kr).
Aziza El Harchi, Andrew S. Butler, Yihong Zhang, Christopher E. Dempsey, Jules C. Hancox   +4 more
doaj   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1771-1784, June 2026.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source

Experience in the Use of Psychocorrection Therapy in the Comprehensive Treatment of Patients with Gastroesophageal Reflux Disease Combined with Dysfunction of the Biliary System

Gastroenterologìa, 2016
Nowadays, due to the rapid increase in the number of stress factors, it is especially important to use psychotherapy and psychopharmacotherapy in the combination treatment of patients with diseases of the gastrointestinal tract.
L.V. Demeshkina, L.M. Mosiychuk, O.P. Petishko, E.V. Zygalo, I.Yu. Zavyalova   +4 more
doaj   +1 more source

Thioridazine Retinopathy

, 1971
Presenting Symptom: Blurred vision OU. Pathology: Mottled retinal pigment. Clinical: The patient was a 30-year old female who complained of blurred vision after receiving 2800 mg of thioridazine daily for 15 days.
David G. Cogan, MD (1908-1993)
core