Results 41 to 50 of about 7,034 (195)

In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs

open access: yesMemorias do Instituto Oswaldo Cruz, 2002
Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum.
Carla MS Menezes   +6 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Modular One‐Pot Access to π‐Expanded Tetrakis(Phenothiazinyl)‐Silanes With Broadly Tunable Redox and Emission Properties

open access: yesChemistry – A European Journal, EarlyView.
A library of 21 tetrakis(phenothiazinyl)‐substituted silanes with broadly variable substituent decoration, which are fully reversible multistage redox systems with intense tunable emission from deep blue to yellow–green (441–533 nm), was rapidly synthesized by bromine–lithium exchange/borylation–Suzuki coupling of tetrakis(4‐bromophenyl)silane or by ...
Thomas P. M. Merke   +4 more
wiley   +1 more source

<b> Photo-oxidative damage to isolated rat liver mitochondria induced by phenothiazines </b>

open access: yesRevista de Ciências Farmacêuticas Básica e Aplicada, 2009
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> Photosensitization is a well-known side-effect of phenothiazines that could involve photochemically promoted oxidative damage ...
T. RODRIGUES   +4 more
doaj  

Electron‐Rich Para‐Methylpyridine‐Functionalized TEMPO Empowers Long‐Lived Neutral Aqueous Organic Redox Flow Batteries

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Three methylpyridine‐functionalized TEMPOs were synthesized through an electron‐rich regulation strategy. The calculation of transition states supported the highest reaction efficiency of para‐MePy‐TEMPOs, which outperformed its analogues to have the best performance of AORFBs, opening a new avenue for exploring TEMPO‐based catholytes.
Shaopeng Wang   +10 more
wiley   +1 more source

Synthesis, Anticancer Activity, and Apoptosis Induction of Novel 3,6-Diazaphenothiazines

open access: yesMolecules, 2019
New 10-substituted derivatives of 3,6-diazaphenothiazine, containing the triple bond linker terminated with tertiary cyclic and acyclic amine groups, were synthesized and screened for their anticancer action.
Beata Morak-Młodawska   +4 more
doaj   +1 more source

Helical Dinaphthothiophenes Reveal the Limits of BN‐Based Optical Tuning

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
A BN‐7‐thia[5]helicene and an analogous CC‐7‐thia[5]helicene were prepared in two efficient synthetic routes. Their geometrical structures barely differ, which allows us to judge the influence of the BN substitution on the electronic properties. The formal substitution of carbon–carbon (CC) units by boron–nitrogen (BN) units is an established strategy ...
Yannik Appiarius   +7 more
wiley   +1 more source

Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives

open access: yesBiomolecules, 2016
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu   +2 more
doaj   +1 more source

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens

open access: yesComputational and Structural Biotechnology Journal, 2020
The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable.
Maytham Hussein   +9 more
doaj   +1 more source

Research progress in photo‐controlled radical involved luminescence materials

open access: yesFlexMat, EarlyView.
This review systematically dissects radical generation mechanisms, triplet‐exciton photophysics, material design strategies, and cutting‐edge applications in smart encryption, environmental sensing, and 3D printing. Abstract In recent years, photo‐controlled radical room‐temperature phosphorescent (RTP) materials have shown significant application ...
Sichen Meng   +8 more
wiley   +1 more source

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