Results 41 to 50 of about 6,668 (192)

Mechanistische Diversität in der photoangeregten Radikal‐Redoxchemie: Eine kritische Evaluierung

Angewandte Chemie, EarlyView.
Für viele prominente Beispiele der Photoredox‐Katalyse wird angenommen, dass sie über die Anregung einer offenschaligen („open‐shell“) Zwischenform des Katalysators ablaufen. Es wird jedoch intensiv darüber diskutiert, ob solche Mechanismen realistisch sind und, falls ja, wie genau sie ablaufen können.
Samuel J. Horsewill, Ryan Phelps, Joshua P. Barham, Daniel J. Scott   +3 more
wiley   +1 more source

Photo-oxidative damage to isolated rat liver mitochondria induced by phenothiazines

Revista de Ciências Farmacêuticas Básica e Aplicada, 2005
Photosensitization is a well-known side-effect of phenothiazines that could involve photochemically promoted oxidative damage to mitochondria, leading to the impairment of metabolic functions and apoptosis.
T. Rodrigues, P.A.F. Faria, F.S. Pessoto, C.G. Santos, I.L. Nantes   +4 more
doaj  

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
10H-1,9-diazaphenothiazine was obtained in the sulphurisation reaction of diphenylamine with elemental sulphur and transformed into new 10-substituted derivatives, containing alkyl and dialkylaminoalkyl groups at the thiazine nitrogen atom.
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz, Kinga Suwińska, Aleksander Shkurenko, Zenon Czuba, Magdalena Jurzak   +8 more
doaj   +1 more source

Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein

Viruses, 2023
Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence ...
Taizhen Liang, Shiqi Xiao, Ziyao Wu, Xi Lv, Sen Liu, Meilin Hu, Guojie Li, Peiwen Li, Xiancai Ma   +8 more
doaj   +1 more source

Mechanistic Diversity in Photoexcited Radical Redox Chemistry: A Critical Evaluation

Angewandte Chemie International Edition, EarlyView.
Many high‐profile examples of photoredox catalysis are proposed to proceed via excitation of an open‐shell intermediate form of the catalyst. However, there is much debate over whether such mechanisms are realistic and, if so, exactly how they can occur.
Samuel J. Horsewill, Ryan Phelps, Joshua P. Barham, Daniel J. Scott   +3 more
wiley   +1 more source

Thiophene-forming one-pot synthesis of three thienyl-bridged oligophenothiazines and their electronic properties

Beilstein Journal of Organic Chemistry, 2016
The pseudo five-component Sonogashira–Glaser cyclization synthesis of symmetrically 2,5-diaryl-substituted thiophenes is excellently suited to access thienyl-bridged oligophenothiazines in a one-pot fashion. Three thienyl-bridged systems were intensively
Dominik Urselmann, Konstantin Deilhof, Bernhard Mayer, Thomas J. J. Müller   +3 more
doaj   +1 more source

An Insight Into the Potentiation Effect of Potassium Iodide on aPDT Efficacy

Frontiers in Microbiology, 2018
Antimicrobial photodynamic therapy (aPDT) is gaining a special importance as an effective approach against multidrug-resistant strains responsible of fatal infections. The addition of potassium iodide (KI), a non-toxic salt, is recognized to increase the
Cátia Vieira, Ana T. P. C. Gomes, Mariana Q. Mesquita, Nuno M. M. Moura, M. Graça P. M. S. Neves, M. Amparo F. Faustino, Adelaide Almeida   +6 more
doaj   +1 more source

<b> Photo-oxidative damage to isolated rat liver mitochondria induced by phenothiazines </b>

Revista de Ciências Farmacêuticas Básica e Aplicada, 2009
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> Photosensitization is a well-known side-effect of phenothiazines that could involve photochemically promoted oxidative damage ...
T. RODRIGUES, P. A.F. FARIA, F. S. PESSOTO, C. G. SANTOS, I. L. NANTES   +4 more
doaj  

Modular One‐Pot Access to π‐Expanded Tetrakis(Phenothiazinyl)‐Silanes With Broadly Tunable Redox and Emission Properties

Chemistry – A European Journal, EarlyView.
A library of 21 tetrakis(phenothiazinyl)‐substituted silanes with broadly variable substituent decoration, which are fully reversible multistage redox systems with intense tunable emission from deep blue to yellow–green (441–533 nm), was rapidly synthesized by bromine–lithium exchange/borylation–Suzuki coupling of tetrakis(4‐bromophenyl)silane or by ...
Thomas P. M. Merke, Lysander Presser, Leonard Karl, Christian Ganter, Thomas J. J. Müller   +4 more
wiley   +1 more source

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens

Computational and Structural Biotechnology Journal, 2020
The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable.
Maytham Hussein, Xiaohan Hu, Olivia K.A. Paulin, Simon Crawford, Qi Tony Zhou, Mark Baker, Elena K. Schneider-Futschik, Yan Zhu, Jian Li, Tony Velkov   +9 more
doaj   +1 more source