Results 11 to 20 of about 7,034 (195)

14-Substituted Diquinothiazines as a New Group of Anticancer Agents

Molecules, 2023
A series of novel double-angularly condensed diquinothiazines with aminoalkyl, amidoalkyl, sulfonamidoalkyl, and substituted phenyl groups was designed, synthesized, and evaluated for their anticancer activity against four selected human tumor cell lines
Małgorzata Jeleń, Krystian Pluta, Małgorzata Szmielew, Beata Morak-Młodawska, Kinga Herman, Klaudia Giercuszkiewicz, Anna Kasprzycka, Magdalena Skonieczna   +7 more
doaj   +1 more source

UV-light effects on cytochrome c modulated by the aggregation state of phenothiazines. [PDF]

PLoS ONE, 2013
The present study shows the factors that modulate the photodamage promoted by phenothiazines. Cytochrome c was irradiated with UV light for 120 min, over a pH range from 4.0 to 8.0, in the absence and in the presence of different concentrations of ...
Carolina G dos Santos, André L Silva, Flavio L Souza, Alexandre J C Lanfredi, Paolo Di Mascio, Otaciro R Nascimento, Tiago Rodrigues, Iseli L Nantes   +7 more
doaj   +1 more source

Evidence of Calcium Signaling and Modulation of the LmrS Multidrug Resistant Efflux Pump Activity by Ca2 + Ions in S. aureus

Frontiers in Microbiology, 2020
Calcium ions (Ca2+) play a pivotal role in eukaryote cell signaling and regulate many physiological functions. Although a similar role for Ca2+ in prokaryotes has been difficult to demonstrate, there is increasing evidence for Ca2+ as a cell regulator in
Amy R. Nava, Natalia Mauricio, Angel J. Sanca, Delfina C. Domínguez, Delfina C. Domínguez   +4 more
doaj   +1 more source

Synthesis and Structural Characterization of Novel Dimers of Dipyridothiazine as Promising Antiproliferative Agents

Molecules, 2023
Many new isomeric dipyridothiazine dimers have been presented as molecules with anticancer potential. These compounds were obtained in efficient syntheses of 1,6-, 1,8-, 2,7- and 3,6-diazaphenothiazines with selected alkylaromatic linkers. The structures
Emilia Martula, Beata Morak-Młodawska, Małgorzata Jeleń, Patrick N. Okechukwu, Abbirami Balachandran, Prethika Tehirunavukarasu, Kirthani Anamalay, Vaidehi Ulaganathan   +7 more
doaj   +1 more source

Synthesis of Bioactive Fluorinated 10H-Phenothiazines and their Sulfone Derivatives

E-Journal of Chemistry, 2008
The present communication deals with the synthesis of a series of fluorinated 10H-phenothiazines. 10H-phenothiazines is prepared by Smiles rearrangement of substituted 2-foramido-2´-nitrodiphenylsulfide.
Yogesh Dixit, Rahul Dixit, Naveen Gautam, D. C. Gautam   +3 more
doaj   +1 more source

Role of Phenothiazines and Structurally Similar Compounds of Plant Origin in the Fight against Infections by Drug Resistant Bacteria

Antibiotics, 2013
Phenothiazines have their primary effects on the plasma membranes of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources and energy providing enzymes, such as ATPase, and ...
Leonard Amaral, Joseph Molnar, Sujata G. Dastidar, Jette E. Kristiansen   +3 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein

Frontiers in Chemistry, 2020
The study of proteins and mechanisms involved in the apoptosis and new knowledge about cancer's biology are essential for planning new drugs. Tumor cells develop several strategies to gain proliferative advantages, including molecular alterations to ...
Aline Lagoeiro do Carmo, Fernanda Bettanin, Michell Oliveira Almeida, Simone Queiroz Pantaleão, Tiago Rodrigues, Paula Homem-de-Mello, Kathia Maria Honorio, Kathia Maria Honorio   +7 more
doaj   +1 more source

Stability Studies of UV Laser Irradiated Promethazine and Thioridazine after Exposure to Hypergravity Conditions

Molecules, 2022
Pharmaceuticals carried into space are subjected to different gravitational conditions. Hypergravity is encountered in the first stage, during spacecraft launching.
Ágota Simon, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Alexandru Stoicu, Alan Dowson, Jack J. W. A. van Loon, Mihail Lucian Pascu   +7 more
doaj   +1 more source

Dithieno[1,4]thiazines and Bis[1]benzothieno[1,4]thiazines—Organometallic Synthesis and Functionalization of Electron Density Enriched Congeners of Phenothiazine

Molecules, 2020
This mini-review summarizes the syntheses and functionalizations of dithieno[1,4]thiazines and bis[1]benzothieno[1,4]thiazines, both electron density-enriched congeners of phenothiazines with remarkable electronic properties.
Lars May, Thomas J. J. Müller
doaj   +1 more source