Results 1 to 10 of about 50,842 (252)

Acetylcholinesterase-Inhibiting Activity of Salicylanilide <em>N</em>-Alkylcarbamates and Their Molecular Docking

Molecules, 2012
A series of twenty-five novel salicylanilide <em>N</em>-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (< ...
Josef Jampilek, Juana Monreal-Ferriz, Jarmila Vinsova, Karel Pauk, Jan Vanco, Sarka Stepankova, Ales Imramovsky   +6 more
doaj   +1 more source

Effect of cyclic substituents on the anti-cancer activity and DNA interaction of ruthenium(II) bis-phenanthroline dipyridoquinoline

Frontiers in Molecular Biosciences, 2023
Introduction: Ruthenium(II) complexes have emerged recently as candidates for anti-cancer therapy, where activity is related to lipohilicity, cellular localization, and specific interactions with biomolecules.Methods: In this work, two novel complexes ...
Etubonesi E. Nyong-Bassey, Andrew L. Hicks, Poppy Bergin, Eimer M. Tuite, Valery Kozhevnikov, Stephany Veuger   +5 more
doaj   +1 more source

Antifeedant Effects of Essential Oil, Extracts, and Isolated Sesquiterpenes from Pilgerodendron uviferum (D. Don) Florin Heartwood on Red Clover Borer Hylastinus obscurus (Coleoptera: Curculionidae)

Molecules, 2018
The beetle Hylastinus obscurus Marsham (Coleoptera: Curculionidae), endemic to Europe and Northern Africa, is one of the most important red clover pests in Chile.
Javier Espinoza, Alejandro Urzúa, Leonardo Bardehle, Andrés Quiroz, Javier Echeverría, Marcia González-Teuber   +5 more
doaj   +1 more source

Application of lipophilicity parameters in QSRR analysis of newly synthesized s-triazine derivatives: Prediction of the retention behavior [PDF]

Hemijska Industrija, 2011
Considerable attention has been paid to the analysis of chemicals in the s-triazine group, due to their widespread use in agricultural chemistry and their subsequent impact on biological systems. For initial chemical screening of the activity of newly
Jevrić Lidija R., Jovanović Bratislav Ž., Velimirović Sonja D., Tepić Aleksandra N., Koprivica Gordana B., Mišljenović Nevena M.   +5 more
doaj   +1 more source

Applications of three-dimensional carbon nanotube networks

Beilstein Journal of Nanotechnology, 2015
In this paper, we show that it is possible to synthesize carbon-based three-dimensional networks by adding sulfur, as growth enhancer, during the synthesis process. The obtained material is self-supporting and consists of curved and interconnected carbon
Manuela Scarselli, Paola Castrucci, Francesco De Nicola, Ilaria Cacciotti, Francesca Nanni, Emanuela Gatto, Mariano Venanzi, Maurizio De Crescenzi   +7 more
doaj   +1 more source

Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity

Frontiers in Medicine, 2022
BackgroundVestibular side effects such as dizziness and vertigo can be a limitation for some antibiotics commonly used to treat acne, rosacea, and other dermatology indications.ObjectiveUnlike minocycline, which is a second-generation tetracycline ...
Ayman Grada, James Q. Del Rosso, James Q. Del Rosso, Angela Y. Moore, Angela Y. Moore, Linda Stein Gold, Julie Harper, Giovanni Damiani, Giovanni Damiani, Giovanni Damiani, Katharina Shaw, Sabine Obagi, Raidah J. Salem, S. Ken Tanaka, Christopher G. Bunick, Christopher G. Bunick   +15 more
doaj   +1 more source

Enhancement of solubility of paclitaxel by applying factorial design

Current Medicine Research and Practice, 2021
Background: The poor aqueous solubility and low bioavailability of antineoplastic drugs restrict the oral route for the cancer therapy. However, specific nanotechnologies developed to address this issue.
Pragya Baghel, Amit Roy, Shekhar Verma, Trilochan Satapathy, Sanjib Bahadur   +4 more
doaj   +1 more source

Investigating the Spectrum of Biological Activity of Ring-Substituted Salicylanilides and Carbamoylphenylcarbamates

Molecules, 2010
In this study, a series of twelve ring-substituted salicylanilides and carbamoylphenylcarbamates were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity.
Josef Jampilek, Des R. Richardson, Jozef Csollei, Aidan Coffey, Zuzana Mandelova, Danuta S. Kalinowski, Marcela Vejsova, Frantisek Sersen, Katarina Kralova, Jiahui Guo, Matus Pesko, Jan Otevrel, Zaklina Kovacevic   +12 more
doaj   +1 more source

Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D₃ and Its Natural Derivatives

Pharmaceuticals, 2020
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements. Multiple hydroxylation reactions in several tissues including liver and small intestine produce different forms of ...
Subrata Deb, Anthony Allen Reeves, Suki Lafortune   +2 more
doaj   +1 more source

QSRR modeling of lipophilicity of new spirohydantoin derivatives determined with various TLC systems

Acta Chimica Slovenica
A Quantitative structure-retention relationship (QSRR) analysis has been carried out on the chromatography parameters of lipophilicity of selected spirohydantoins. Multiple linear regression (MLR) was applied for construct the QSRR models.
Kristina Tot, Anita Lazić, Tatjana Djaković Sekulić   +2 more
doaj   +1 more source