Results 41 to 50 of about 130,911 (332)
Journal of Analytical Methods in Chemistry, 2019 The problem of designing a new drug is nowadays very important for researches representing many branches of science. This work considers the usefulness of the analytical method such as thin-layer chromatography for the lipophilicity of newly synthesized ...
Katarzyna Bober +2 more
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Lipophilicity Study of Fumaric and Maleic Acids
, 2023 The experimental lipophilicity of fumaric acid (FA) and maleic acid (MA) using the traditional shake-flask method in an n-octanol–water system using reversed-phase thin-layer chromatography (RP-TLC) was determined.
Alina Pyka-Pająk, Daria Klimoszek
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Chemistry Proceedings, 2022 A series of twenty-two monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides designed as dual anti-invasive agents was prepared and characterized. Lipophilicity significantly affects biological activities of compounds and ADME properties; therefore,
Tomas Gonec +5 more
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Chemosensitization by lipophilic nitroimidazoles [PDF]
British Journal of Cancer, 1983 We have carried out experiments to determine the response of tumours and normal tissues in the C3H mouse to the combination of lipophilic nitroimidazoles and CCNU, cyclophosphamide or melphalan. The nitroimidazoles studied were Ro 07-1902 (1902) and benznidazole (Ro 07-1051, BENZO). Maximum enhancement of CCNU response in the KHT sarcoma by 2.5 mmol kg-
P R, Twentyman, P, Workman
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Journal of Chemistry, 2013 Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water.
Andrzej Czyrski, Bartłomiej Kupczyk
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, 2014 Citation: 'lipophilicity' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.LT06965 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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MoleculesThis study represents the first-time experimental analysis of lipophilicity for antidiabetic drugs from the gliflozin class using chromatographic methods alongside computational approaches.
Anna Gumieniczek +3 more
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Investigation of Hydro-Lipophilic Properties of N-Alkoxyphenylhydroxynaphthalenecarboxamides †
Molecules, 2018 The evaluation of the lipophilic characteristics of biologically active agents is indispensable for the rational design of ADMET-tailored structure–activity models.
Iva Kapustikova +5 more
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Is there enough focus on lipophilicity in drug discovery?
Expert Opinion on Drug Discovery, 2019 Drug discovery is an expensive and prolonged process with a new drug molecule requiring approximately 12–15 years of development and an estimated $2.6 billion to reach the market as an effective therapeutic agent [1].
S. Lobo
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