Results 61 to 70 of about 130,911 (332)

Transformações Metabólicas de Agrotóxicos em Peixes: Uma Revisão

Orbital: The Electronic Journal of Chemistry, 2016
Fish are among the organisms most damaged by aquatic contamination by pesticides, being ecologically relevant for their bioaccumulation and biomagnification skills of contaminants, which may present health risks to fish consumers.
Ligia Maria Borges Marques Santana, Rivelino Martins Cavalcante   +1 more
doaj   +3 more sources

Predicting retention on immobilized artificial membrane chromatography: Lipophilicity-based versus lipophilicity-independent models

Retention of molecules on immobilized artificial membrane (IAM) chromatography is a key physicochemical property for predictive models of permeability across biological barriers, with applications in drug design and ecotoxicology.
Tsopelas, Fotios, Vallianatou, Theodosia, Tsantili-Kakoulidou, Anna   +2 more
core   +2 more sources

Assessment of the Lipophilicity of Indole Derivatives of Betulin and Their Toxicity in a Zebrafish Model

Molecules
There are scientific studies indicating that the attachment of an indole moiety to the triterpene scaffold can lead to increased anticancer potential.
Zuzanna Rzepka, Katarzyna Bober-Majnusz, Justyna Magdalena Hermanowicz, Ewa Bębenek, Elwira Chrobak, Arkadiusz Surażyński, Dorota Wrześniok   +6 more
doaj   +1 more source

Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system

ADMET and DMPK, 2020
The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process.
Alejandro Fernández-Pumarega, Belén Martín-Sanz, Susana Amézqueta, Elisabet Fuguet, Martí Rosés   +4 more
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Quantitative Relationships Between Structure and Lipophilicity of Naturally Occurring Polyphenols

Acta Chimica Slovenica, 2014
The lipophilicity of polyphenols inherent in food, beverages, and medicinal plants was modelled by using 3D descriptors derived from optimized 3D molecular structures in combination with 2D descriptors.
Vesna Rastija, Sonja Nikolić, Vijay H. Masand   +2 more
doaj  

Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches

International Journal of Molecular Sciences, 2019
Lipophilicity is a vital physicochemical parameter of a molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties.
Krzesimir Ciura, J. Fedorowicz, F. Andrić, K. Greber, Alina Gurgielewicz, W. Sawicki, J. Sączewski   +6 more
semanticscholar   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Biological Evaluation of 3-Benzylidenechromanones and Their Spiropyrazolines-Based Analogues

Molecules, 2020
A series of 3-benzylidenechrmanones 1, 3, 5, 7, 9 and their spiropyrazoline analogues 2, 4, 6, 8, 10 were synthesized. X-ray analysis confirms that compounds 2 and 8 crystallize in a monoclinic system in P21/n space groups with one and three molecules in
Angelika A. Adamus-Grabicka, Magdalena Markowicz-Piasecka, Marcin Cieślak, Karolina Królewska-Golińska, Paweł Hikisz, Joachim Kusz, Magdalena Małecka, Elzbieta Budzisz   +7 more
doaj   +1 more source

Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists [PDF]

Archives of Biological Sciences, 2016
In the present study, we investigated the relationships between several molecular properties and bioavailability data for seven of the most commonly prescribed angiotensin II receptor antagonists (also known as angiotensin II receptor blockers ...
Trbojević Jovana B., Odović Jadranka V., Trbojević-Stanković Jasna B., Nešić Dejan M., Jelić Ratomir M.   +4 more
doaj   +1 more source