Results 51 to 60 of about 47,589 (249)

Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles

Molecules
The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug ...
Beata Paw, Rafał Śliwa, Łukasz Komsta, Bogusław Senczyna, Monika Karpińska, Joanna Matysiak   +5 more
doaj   +1 more source

Acetylcholinesterase-Inhibiting Activity of Salicylanilide <em>N</em>-Alkylcarbamates and Their Molecular Docking

Molecules, 2012
A series of twenty-five novel salicylanilide <em>N</em>-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (< ...
Josef Jampilek, Juana Monreal-Ferriz, Jarmila Vinsova, Karel Pauk, Jan Vanco, Sarka Stepankova, Ales Imramovsky   +6 more
doaj   +1 more source

Effect of cyclic substituents on the anti-cancer activity and DNA interaction of ruthenium(II) bis-phenanthroline dipyridoquinoline

Frontiers in Molecular Biosciences, 2023
Introduction: Ruthenium(II) complexes have emerged recently as candidates for anti-cancer therapy, where activity is related to lipohilicity, cellular localization, and specific interactions with biomolecules.Methods: In this work, two novel complexes ...
Etubonesi E. Nyong-Bassey, Andrew L. Hicks, Poppy Bergin, Eimer M. Tuite, Valery Kozhevnikov, Stephany Veuger   +5 more
doaj   +1 more source

Wearable OLED‐Assisted Photodynamic Cancer Therapy Using Chlorin e6‐Loaded Pluronic Nanocapsules as Photosensitizers

Advanced Healthcare Materials, EarlyView.
A novel photodynamic therapeutic approach has been employed for anticancer therapy, utilizing chlorin e6‐loaded Pluronic nanocapsules and a wearable organic light‐emitting diode light source. This has shown significant in vivo antitumor efficacy with minimal off‐target toxicity. The innovative combination of a wearable light source and photosensitizers
Hyeryeon Oh, Seung Min Jeong, Cheol Hui Park, Panmo Son, Yeseo Lee, Heebeom Koo, Won Il Choi, Kyung Cheol Choi   +7 more
wiley   +1 more source

Lipophilicity Studies on Thiosemicarbazide Derivatives [PDF]

Molecules, 2017
The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol–water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations.
Agata Paneth, Anna Hawrył, Tomasz Plech, Mirosław Hawrył, Ryszard Świeboda, Dominika Janowska, Monika Wujec, Piotr Paneth   +7 more
openaire   +4 more sources

Antifeedant Effects of Essential Oil, Extracts, and Isolated Sesquiterpenes from Pilgerodendron uviferum (D. Don) Florin Heartwood on Red Clover Borer Hylastinus obscurus (Coleoptera: Curculionidae)

Molecules, 2018
The beetle Hylastinus obscurus Marsham (Coleoptera: Curculionidae), endemic to Europe and Northern Africa, is one of the most important red clover pests in Chile.
Javier Espinoza, Alejandro Urzúa, Leonardo Bardehle, Andrés Quiroz, Javier Echeverría, Marcia González-Teuber   +5 more
doaj   +1 more source

Application of lipophilicity parameters in QSRR analysis of newly synthesized s-triazine derivatives: Prediction of the retention behavior [PDF]

Hemijska Industrija, 2011
Considerable attention has been paid to the analysis of chemicals in the s-triazine group, due to their widespread use in agricultural chemistry and their subsequent impact on biological systems. For initial chemical screening of the activity of newly
Jevrić Lidija R., Jovanović Bratislav Ž., Velimirović Sonja D., Tepić Aleksandra N., Koprivica Gordana B., Mišljenović Nevena M.   +5 more
doaj   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Applications of three-dimensional carbon nanotube networks

Beilstein Journal of Nanotechnology, 2015
In this paper, we show that it is possible to synthesize carbon-based three-dimensional networks by adding sulfur, as growth enhancer, during the synthesis process. The obtained material is self-supporting and consists of curved and interconnected carbon
Manuela Scarselli, Paola Castrucci, Francesco De Nicola, Ilaria Cacciotti, Francesca Nanni, Emanuela Gatto, Mariano Venanzi, Maurizio De Crescenzi   +7 more
doaj   +1 more source

Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity

Frontiers in Medicine, 2022
BackgroundVestibular side effects such as dizziness and vertigo can be a limitation for some antibiotics commonly used to treat acne, rosacea, and other dermatology indications.ObjectiveUnlike minocycline, which is a second-generation tetracycline ...
Ayman Grada, James Q. Del Rosso, James Q. Del Rosso, Angela Y. Moore, Angela Y. Moore, Linda Stein Gold, Julie Harper, Giovanni Damiani, Giovanni Damiani, Giovanni Damiani, Katharina Shaw, Sabine Obagi, Raidah J. Salem, S. Ken Tanaka, Christopher G. Bunick, Christopher G. Bunick   +15 more
doaj   +1 more source