Results 51 to 60 of about 130,911 (332)
Assessment of Bioavailability Parameters of Mono- and Bistriazole Derivatives of Propynoylbetulin
Applied SciencesBioavailability describes the properties that determine the passage of a compound through biological barriers. In many cases, bioavailability depends on the lipophilicity of the compound.
Monika Kadela-Tomanek +5 more
doaj +1 more source
The Journal of pharmacy and pharmacology, 2018 This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies.
Felix Ditzinger +12 more
semanticscholar +1 more source
Studia Universitatis Babes-Bolyai Chemia, 2019 Quantitative structure-retention relationships (QSRR) approach was used to model chromatographic lipophilicity of sixteen proteinogenic amino acids using molecular descriptors computed with DRAGON and ALCHEMY software packages.
Alexandrina GUIDEA, Costel SÂRBU
doaj +1 more source
Journal of chemistry, 2019 The lipophilicity is an important parameter that influences the activity of the drugs in the human body. The reversed phase high performance thin layer chromatography was applied to determine the Log P values of ibuprofen, ketoprofen, naproxen, and ...
A. Czyrski
semanticscholar +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Lipophilicity of Peptide Anions: An Experimental Data Set for Lipophilicity Calculations [PDF]
The Journal of Physical Chemistry B, 2003 For the first time, the standard Gibbs energies of the transfer of peptide anions from aqueous solution to nitrobenzene were determined with the help of electrochemical measurements. These systematic studies clearly show that the lipohilicity contributions of single amino acid residues to the overall lipohilicity of a peptide anion strongly depend on ...
Gulaboski, Rubin, Scholz, Fritz
openaire +2 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Lipophilicity Studies on Thiosemicarbazide Derivatives [PDF]
Molecules, 2017 The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol–water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations.
Agata Paneth +7 more
openaire +4 more sources
Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications
Advanced Functional Materials, EarlyView.Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett +7 more
wiley +1 more source