Results 51 to 60 of about 50,842 (252)

Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles

Molecules
The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug ...
Beata Paw, Rafał Śliwa, Łukasz Komsta, Bogusław Senczyna, Monika Karpińska, Joanna Matysiak   +5 more
doaj   +1 more source

Lipophilicity Studies on Thiosemicarbazide Derivatives [PDF]

Molecules, 2017
The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol–water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations.
Agata Paneth, Anna Hawrył, Tomasz Plech, Mirosław Hawrył, Ryszard Świeboda, Dominika Janowska, Monika Wujec, Piotr Paneth   +7 more
openaire   +4 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Impact of lipophilic carriers on metronidazole lipophilicity

Tropical Journal of Pharmaceutical Research
Purpose: To optimize the lipophilicity of metronidazole using two lipophilic carriers (stearic acid and cholesterol). Methods: The partition coefficient of compounds was determined using the shake flask method. The classical method included shaking a sample in a flask to equilibrate it between an aqueous phase and an organic phase.
Abood, Ahmed, Abdul-nabi, Zainab
openaire   +2 more sources

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Eutectic Gallium‐Indium as a Potential Non‐Toxic Replacement in Mercury Intrusion Porosimetry

Advanced Materials Technologies, EarlyView.
A practical alternative to mercury intrusion porosimetry is presented using non‐oxidized eutectic gallium‐indium. An eGaIn Filling Station enables oxygen‐free preparation of standard penetrometers, and the resulting measurements faithfully reproduce pore‐size distributions and intrusion volumes measured with mercury across several standard reference ...
Denis Schuetz, Michael F. Noisternig, Manuel Brandstaetter, Valentin Seyfried, Norbert Reitinger, Bernhard Nell, Alexander Kasper, Riaz Ahmad, Martin Thomas   +8 more
wiley   +1 more source

Lipophilicity in Drug Design: An Overview of Lipophilicity Descriptors in 3D-QSAR Studies [PDF]

Future Medicinal Chemistry, 2019
The pharmacophore concept is a fundamental cornerstone in drug discovery, playing a critical role in determining the success of in silico techniques, such as virtual screening and 3D-QSAR studies. The reliability of these approaches is influenced by the quality of the physicochemical descriptors used to characterize the chemical entities.
Ginex, Tiziana, Vázquez, Javier, Gibert, Enric, Herrero, Enric, Luque Garriga, F. Xavier   +4 more
openaire   +3 more sources

Hydro‐ and Lipophilicity of Molecular‐Size‐Controlled Hydrogel Drug Carriers

Advanced Materials Technologies, EarlyView.
We investigate nano‐sized hydrogel drug carriers with tailored hydro‐ and lipophilicity. We design their encapsulation and structure‐forming capabilities and follow them in real time during fabrication using time‐resolved and in situ grazing incidence x‐ray scattering.
Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavillet, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Gordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller‐Buschbaum, Henrike M. Müller‐Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez‐Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert   +21 more
wiley   +1 more source

lipophilic

, 2014
Citation: 'lipophilic' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.L03572 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source