Results 71 to 80 of about 130,911 (332)

Synthesis and Critical View on the Structure-Activity Relationships of N-(Substituted phenyl)-/N-Diphenylmethyl-piperazine-Based Conjugates as Antimycobacterial Agents

Applied Sciences, 2021
This research focused on a three-step synthesis, analytical, physicochemical, and biological evaluation of hybrid molecules 6a–g, containing a lipophilic 3-trifluoromethylphenyl moiety, polar carbamoyloxy bridge, 2-hydroxypropan-1,3-diyl chain and 4 ...
Jana Čurillová, Mária Pecháčová, Tereza Padrtová, Daniel Pecher, Šárka Mascaretti, Josef Jampílek, Ľudmila Pašková, František Bilka, Gustáv Kováč, Ivan Malík   +9 more
doaj   +1 more source

Impact of lipophilic carriers on metronidazole lipophilicity

Tropical Journal of Pharmaceutical Research
Purpose: To optimize the lipophilicity of metronidazole using two lipophilic carriers (stearic acid and cholesterol). Methods: The partition coefficient of compounds was determined using the shake flask method. The classical method included shaking a sample in a flask to equilibrate it between an aqueous phase and an organic phase.
Ahmed Abood, Zainab Abdul-nabi
openaire   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles

Molecules
The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug ...
Beata Paw, Rafał Śliwa, Łukasz Komsta, Bogusław Senczyna, Monika Karpińska, Joanna Matysiak   +5 more
doaj   +1 more source

Plasticizer Effects in the PVC Membrane of the Dibasic Phosphate Selective Electrode

Chemosensors, 2015
The PVC membrane of an ion-selective electrode (ISE) sensitive to dibasic phosphate ions (HPO4-ISE) has not been optimized for maximum selectivity, sensitivity, and useable ISE lifetime and further work was necessary to improve its performance. Two areas
Clifton Carey
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

A Comparative Study of the Lipophilicity of Metformin and Phenformin

Molecules, 2021
The results presented in this paper confirm the beneficial role of an easy-to-use and low-cost thin-layer chromatography (TLC) technique for describing the retention behavior and the experimental lipophilicity parameter of two biguanide derivatives ...
Małgorzata Dołowy, Josef Jampilek, Katarzyna Bober-Majnusz   +2 more
doaj   +1 more source

Counterintuitive Fluorescence Blue Shift in Symmetry Breaking Dicationic Bis(indolium) with Two‐Photon Absorption Properties for NIR Living Cell Imaging

Advanced Materials, EarlyView.
Highly water‐soluble dicationic bis(indolium) dyes have been prepared, showing excellent two‐photon absorption and light emission. Their fluorescence behavior discloses an unusual increasing blue shift with increasing solvent polarity, which, in parallel, is beneficial for enhanced detection in biological media.
Carlos Benitez‐Martin, Jose M. Marin‐Beloqui, Juan T. López Navarrete, Juan Casado, Francisco Najera, Ezequiel Perez‐Inestrosa   +5 more
wiley   +1 more source

Acetylcholinesterase-Inhibiting Activity of Salicylanilide <em>N</em>-Alkylcarbamates and Their Molecular Docking

Molecules, 2012
A series of twenty-five novel salicylanilide <em>N</em>-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (< ...
Josef Jampilek, Juana Monreal-Ferriz, Jarmila Vinsova, Karel Pauk, Jan Vanco, Sarka Stepankova, Ales Imramovsky   +6 more
doaj   +1 more source

Effect of cyclic substituents on the anti-cancer activity and DNA interaction of ruthenium(II) bis-phenanthroline dipyridoquinoline

Frontiers in Molecular Biosciences, 2023
Introduction: Ruthenium(II) complexes have emerged recently as candidates for anti-cancer therapy, where activity is related to lipohilicity, cellular localization, and specific interactions with biomolecules.Methods: In this work, two novel complexes ...
Etubonesi E. Nyong-Bassey, Andrew L. Hicks, Poppy Bergin, Eimer M. Tuite, Valery Kozhevnikov, Stephany Veuger   +5 more
doaj   +1 more source