Results 31 to 40 of about 50,842 (252)

Development and Validation of Liquid Chromatography-Based Methods to Assess the Lipophilicity of Cytotoxic Platinum(IV) Complexes

Inorganics, 2018
Lipophilicity is a crucial parameter for drug discovery, usually determined by the logarithmic partition coefficient (Log P) between octanol and water.
Matthias H. M. Klose, Sarah Theiner, Hristo P. Varbanov, Doris Hoefer, Verena Pichler, Markus Galanski, Samuel M. Meier-Menches, Bernhard K. Keppler   +7 more
doaj   +1 more source

Assessment of Bioavailability Parameters of Mono- and Bistriazole Derivatives of Propynoylbetulin

Applied Sciences
Bioavailability describes the properties that determine the passage of a compound through biological barriers. In many cases, bioavailability depends on the lipophilicity of the compound.
Monika Kadela-Tomanek, Arkadiusz Sokal, Klaudia Stocerz, Ewa Bębenek, Elwira Chrobak, Paweł Olczyk   +5 more
doaj   +1 more source

MODELING AND PREDICTION OF AMINO ACIDS LIPOPHYLICITY USING MULTIPLE LINEAR REGRESSION COUPLED WITH GENETIC ALGORITHM

Studia Universitatis Babes-Bolyai Chemia, 2019
Quantitative structure-retention relationships (QSRR) approach was used to model chromatographic lipophilicity of sixteen proteinogenic amino acids using molecular descriptors computed with DRAGON and ALCHEMY software packages.
Alexandrina GUIDEA, Costel SÂRBU
doaj   +1 more source

Transformações Metabólicas de Agrotóxicos em Peixes: Uma Revisão

Orbital: The Electronic Journal of Chemistry, 2016
Fish are among the organisms most damaged by aquatic contamination by pesticides, being ecologically relevant for their bioaccumulation and biomagnification skills of contaminants, which may present health risks to fish consumers.
Ligia Maria Borges Marques Santana, Rivelino Martins Cavalcante   +1 more
doaj   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography

Journal of Chemistry, 2013
Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water.
Andrzej Czyrski, Bartłomiej Kupczyk
doaj   +1 more source

Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system

ADMET and DMPK, 2020
The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process.
Alejandro Fernández-Pumarega, Belén Martín-Sanz, Susana Amézqueta, Elisabet Fuguet, Martí Rosés   +4 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Assessment of the Lipophilicity of Indole Derivatives of Betulin and Their Toxicity in a Zebrafish Model

Molecules
There are scientific studies indicating that the attachment of an indole moiety to the triterpene scaffold can lead to increased anticancer potential.
Zuzanna Rzepka, Katarzyna Bober-Majnusz, Justyna Magdalena Hermanowicz, Ewa Bębenek, Elwira Chrobak, Arkadiusz Surażyński, Dorota Wrześniok   +6 more
doaj   +1 more source