Results 21 to 30 of about 47,589 (249)
Lipophilicity of morphine microspecies and their contribution to the lipophilicity profile
European Journal of Pharmaceutical Sciences, 2012 The complete set of experimental microscopic partition coefficients of morphine was determined for the first time for any compound. The acid-base microequilibria were characterized by combining pH-potentiometry and deductive methods using auxiliary compounds of reduced complexity.
Károly, Mazák, Béla, Noszál
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Molecules, 2022 Sulfonamides are a classic group of chemotherapeutic drugs with a broad spectrum of pharmacological action, including anticancer activity. In this work, reversed-phase high-performance liquid chromatography and biomimetic chromatography were applied to ...
Monika Pastewska +8 more
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Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups
Beilstein Journal of Organic Chemistry, 2020 A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds.
Benjamin Jeffries +9 more
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, 2014 Citation: 'lipophilicity' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.LT06965 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Journal of Analytical Methods in Chemistry, 2019 The subject of the study was 11 new synthetized tetracyclic diazaphenothiazine derivatives. Using thin-layer chromatography in a reverse phase system (RP-TLC), their RM0 lipophilicity parameter was determined.
Anna Nycz–Empel +4 more
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Examination of lipophilicity and toxicity of azo dyes derivatives
Zaštita Materijala, 2017 Azo dyes, in addition to showing a wide range of applications in various industries, after releasing into aquatic ecosystems can act as pollutants. The first step in the prediction of possible toxic effects of compounds in the environment includes the ...
Suzana Apostolov +3 more
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Journal of Analytical Methods in Chemistry, 2019 The problem of designing a new drug is nowadays very important for researches representing many branches of science. This work considers the usefulness of the analytical method such as thin-layer chromatography for the lipophilicity of newly synthesized ...
Katarzyna Bober +2 more
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Chemistry Proceedings, 2022 A series of twenty-two monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides designed as dual anti-invasive agents was prepared and characterized. Lipophilicity significantly affects biological activities of compounds and ADME properties; therefore,
Tomas Gonec +5 more
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Inorganics, 2018 Lipophilicity is a crucial parameter for drug discovery, usually determined by the logarithmic partition coefficient (Log P) between octanol and water.
Matthias H. M. Klose +7 more
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Chemosensitization by lipophilic nitroimidazoles [PDF]
British Journal of Cancer, 1983 We have carried out experiments to determine the response of tumours and normal tissues in the C3H mouse to the combination of lipophilic nitroimidazoles and CCNU, cyclophosphamide or melphalan. The nitroimidazoles studied were Ro 07-1902 (1902) and benznidazole (Ro 07-1051, BENZO). Maximum enhancement of CCNU response in the KHT sarcoma by 2.5 mmol kg-
P R, Twentyman, P, Workman
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