Results 21 to 30 of about 130,911 (332)
Lipophilicity and biomimetic properties to support drug discovery
Expert Opinion on Drug Discovery, 2017 Introduction: Lipophilicity, expressed as the octanol-water partition coefficient, constitutes the most important property in drug action, influencing both pharmacokinetic and pharmacodynamics processes as well as drug toxicity.
Tsopelas, F. +2 more
core +2 more sources
A story of peptides, lipophilicity and chromatography – back and forth in time
RSC Medicinal Chemistry, 2022 Peptides, as part of the beyond the rule of 5 (bRo5) chemical space, represent a unique class of pharmaceutical compounds. Because of their exceptional position in the chemical space between traditional small molecules (molecular weight (MW) < 500 Da ...
V. Erckes, Christian Steuer
semanticscholar +1 more source
Pharmaceutics, 2021 A key parameter in the design of new active compounds is lipophilicity, which influences the solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic and toxicological profiles of compounds.
Monika Kadela-Tomanek +5 more
semanticscholar +1 more source
Effects of Replacing Oxygenated Functionality with Fluorine on Lipophilicity.
Journal of Medicinal Chemistry, 2021 The replacement of oxygenated functionality (hydroxy and alkoxy) with a fluorine atom is a commonly used bioisosteric replacement in medicinal chemistry.
R. Glyn, G. Pattison
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2021 Cyclic peptides have received increasing attention over the recent years as potential therapeutics for "undruggable" targets. One major obstacle is, however, their often relatively poor bioavailability.
Shuzhe Wang +5 more
semanticscholar +1 more source
Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2021 Lipophilicity plays a significant role in the permeability of the drugs through cell membranes and impacts the drug activity in the human body. In this paper, the spectrophotometric method was used to determine the apparent partition coefficients of two ...
A. Czyrski
semanticscholar +1 more source
Journal of Cheminformatics, 2020 Efficient and accurate prediction of molecular properties, such as lipophilicity and solubility, is highly desirable for rational compound design in chemical and pharmaceutical industries.
Bowen Tang +5 more
semanticscholar +1 more source
ACS Nano, 2021 A mechanistic understanding of how the surface properties of engineered nanomaterials influence their interactions with cells is essential for designing materials for applications such as bioimaging and drug delivery, as well as for assessing ...
Christian A Lochbaum +5 more
semanticscholar +1 more source
Hydrophilic or Lipophilic Statins? [PDF]
Frontiers in Cardiovascular Medicine, 2021 Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins (rosuvastatin and pravastatin) present greater hepatoselectivity.
Elisenda Climent +7 more
openaire +5 more sources
Medical Sciences Forum, 2022 The aim of this work was the use of both cluster analysis (CA) and Principal Component Analysis (PCA) for the evaluation of the lipophilicity of selected antiandrogen drugs such as abiraterone, bicalutamide, flutamide, nilutamide, leflunomide ...
Dawid Wardecki +2 more
doaj +1 more source