Results 11 to 20 of about 47,589 (249)
PharmaceuticalsLipophilicity is one of the principal parameters that describe the pharmacokinetic behavior of a drug, including its absorption, distribution, metabolism, elimination, and toxicity.
Beata Morak-Młodawska +2 more
exaly +3 more sources
Molecules, 2017 In this study, we tested eight naturally-occurring flavonoids—three flavanones and five flavones—for their possible antibacterial properties against four Gram-positive and four Gram-negative bacteria.
Javier Echeverría +2 more
exaly +3 more sources
A Comparative Study of the Lipophilicity of Metformin and Phenformin
Molecules, 2021 The results presented in this paper confirm the beneficial role of an easy-to-use and low-cost thin-layer chromatography (TLC) technique for describing the retention behavior and the experimental lipophilicity parameter of two biguanide derivatives ...
Katarzyna Bober-Majnusz +2 more
exaly +3 more sources
Comparative chemometric analysis, ranking and selection of lipophilicity parameters of 6-chloro-1,3,5-triazine derivatives with acyclic and cyclic substituents [PDF]
Acta Periodica Technologica, 2022 In the present paper, the chemometric analysis, ranking and selection of the most suitable in silico lipophilicity parameters of eight alkyl and cycloalkyl s-triazine derivatives were carried out.
Salaković Benjamin +5 more
doaj +1 more source
Molecules, 2022 This study aimed to evaluate the lipophilicity of a series substances lowering the concentration of uric acid in blood and anti-androgen drugs by thin-layer chromatography in reversed-phase systems (RP-TLC, RP-HPTLC) and computational methods.
Dawid Wardecki +3 more
doaj +1 more source
Lipophilicity and ADMET Analysis of Quinoline-1,4-quinone Hybrids
Pharmaceutics, 2022 Lipophilicity is one of the basic properties of a potential drug determining its solubility in non-polar solvents and, consequently, its ability to passively penetrate the cell membrane, as well as the occurrence of various pharmacokinetic processes ...
Monika Kadela-Tomanek +3 more
doaj +1 more source
Density functional theory calculation of lipophilicity for organophosphate type pesticides [PDF]
Journal of the Serbian Chemical Society, 2017 Density functional method with continuum solvation model is used for calculation of partition coefficient logKOW and determination of lipophilicity of 22 most frequently used organophosphate type pesticides. Excellent agreement with experimental
Vlahović Filip +3 more
doaj +1 more source
Medical Sciences Forum, 2022 The aim of this work was the use of both cluster analysis (CA) and Principal Component Analysis (PCA) for the evaluation of the lipophilicity of selected antiandrogen drugs such as abiraterone, bicalutamide, flutamide, nilutamide, leflunomide ...
Dawid Wardecki +2 more
doaj +1 more source
Correlation between the lipophilicity and antifungal activity of some benzoxazole derivatives [PDF]
Acta Periodica Technologica, 2010 In the present work, a quantitative relationship between the lipophilicity and antifungal activity of some benzoxazole derivatives against Candida albicans was investigated by using QSAR (quantitative structure-activity relationship) analyses.
Podunavac-Kuzmanović Sanja O. +1 more
doaj +1 more source
Hydrophilic or Lipophilic Statins? [PDF]
Frontiers in Cardiovascular Medicine, 2021 Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins (rosuvastatin and pravastatin) present greater hepatoselectivity.
Elisenda Climent +7 more
openaire +5 more sources