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Australian and New Zealand Journal of Medicine, 1972
Summary: Chlorpromazine and other tranquillizers cause a precipitation of the protein and glycoprotein components of bile in vitro. This precipitation depends on an interaction between the carboxyl groups on the protein and glycoprotein components of bile and the positively charged amine groups on the drug molecules in solution.
Michael A. Denborough +2 more
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Summary: Chlorpromazine and other tranquillizers cause a precipitation of the protein and glycoprotein components of bile in vitro. This precipitation depends on an interaction between the carboxyl groups on the protein and glycoprotein components of bile and the positively charged amine groups on the drug molecules in solution.
Michael A. Denborough +2 more
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Phenothiazines as Anticholinergics
Journal of Pharmaceutical Sciences, 1971The synthesis and anticholinergic activity of a new series of quaternary oximes of some 10-N-substituted phenothiazines are reported.
R. L. Mital +4 more
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Phenothiazin‐Bipyridinium‐Oligooxacyclophane
Angewandte Chemie, 1993Überraschenderweise zeigt das [11.11]Cyclophan 1(n= 3) in Dichlormethan und Acetonitril transanulare Nuclear‐Overhauser‐Effekte (NOEs) zwischen den Protonen der Bipyridinium‐ und denen der Phenothiazin‐Komponente, was für eine attraktive Donor‐Acceptor‐Wechselwirkung spricht. Durch Komplexierung mit Barium‐Ionen kommen sich auch im [20.20]Cyclophan1(n=
Petry, C. +3 more
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Journal of Mental Science, 1962
Patients in the care of the Department of Psychological Medicine, Guy's Hospital, who are receiving moderate and large doses of phenothiazine drugs are regularly tested for evidence of hepatic or haematological disturbance. In the course of such an investigation, when the urine of a schizophrenic patient was tested with modified Ehrlich's reagent for ...
R. G. Huntsman, P. D. Griffiths, S. Gold
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Patients in the care of the Department of Psychological Medicine, Guy's Hospital, who are receiving moderate and large doses of phenothiazine drugs are regularly tested for evidence of hepatic or haematological disturbance. In the course of such an investigation, when the urine of a schizophrenic patient was tested with modified Ehrlich's reagent for ...
R. G. Huntsman, P. D. Griffiths, S. Gold
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Drug Metabolism and Drug Interactions, 1994
Phenothiazine, the parent compound of a multitude of present-day drugs, has been employed on an extensive scale for its insecticidal, fungicidal, antibacterial and anthelmintic properties. Almost a catholicon, its widespread use in animals and man has led to the uncovering of many adverse reactions encompassing effects on blood elements, neuromuscular ...
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Phenothiazine, the parent compound of a multitude of present-day drugs, has been employed on an extensive scale for its insecticidal, fungicidal, antibacterial and anthelmintic properties. Almost a catholicon, its widespread use in animals and man has led to the uncovering of many adverse reactions encompassing effects on blood elements, neuromuscular ...
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Structures of benzo[a]phenothiazine and benzo[c]phenothiazine
Acta Crystallographica Section C Crystal Structure Communications, 1993Benzo[a]phenothiazine (I), C 16 H 11 NS, M r =249.3, monoclinic, P2 1 /a, a=25.269 (2), b=23.347 (2), c=8.306 (2) A, β=91.71 (1) o , V=4898 (1) A 3 , Z=16, D m =1.35, D x =1.35 Mg m -3 , λ(Mo Kα)=0.71073 A, μ=0.23 mm -1 , F(000)=2080, T=293 K, R=0.069 for 4248 observed reflections. Benzo[c]phenothiazine (II), C 16 H 11 NS, M r =249.3, monoclinic, P2 1 /
K. Kozawa +3 more
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British Journal of Psychiatry, 1969
The case history is reported here of a woman who has developed involuntary movements while having prolonged phenothiazine therapy. The disorder has developed gradually and is apparently irreversible. It has some unusual features.
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The case history is reported here of a woman who has developed involuntary movements while having prolonged phenothiazine therapy. The disorder has developed gradually and is apparently irreversible. It has some unusual features.
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