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Cytotoxic Potential of Phenothiazines
Current Drug Targets, 2006Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the relatively lower cytotoxicity. Phenothiazines have been used for clinical treatments as psychotropics.
Kazue Satoh +3 more
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Cardiovascular effects of phenothiazines
American Heart Journal, 1980Abstract Phenothiazines have significant electrophysiologic and cardiocirculatory effects. The electrophysiologic effect of these drugs is similar to that reported for quinidine. Phenothiazines decrease the rate of rise of phase 0 of the action potential, decrease the duration and amplitude of phase 2, and prolong phase 3.
William Frishman +3 more
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The Toxicity of Coroxon/Phenothiazine and Coumaphos/Phenothiazine
Research in Veterinary Science, 1962SUMMARY —Experiments are described which show that anthelmintic doses of mixtures of Coroxon/phenothiazine or Coumaphos/phenothiazine are well tolerated by sheep of all ages and by sheep under various environmental conditions. Metabolism studies with Coroxon/phenothiazine showed that over 90 per cent of an oral dose (6 mg./ kg.) of Coroxon was ...
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Paradoxical effects of phenothiazines
The Psychiatric Quarterly, 1968Four patients have been described as showing a most unusual paradoxical reaction to phenothiazines at extremely low doses. The theoretical aspects of the problem have been considered.
Herman C. B. Denber +2 more
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The Long-Acting Phenothiazines
Archives of General Psychiatry, 1975Injected intramuscularly, the enanthane and decanoate esters of the phenothiazine fluphenazine are an effective treatment of the disordered behavior and thinking of schizophrenia. The decanoate preparation is not only slightly longer-acting but also has a smaller incidence of side-effects that the enanthate.
James E. Groves, Michel R. Mandel
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Infrared Study of Phenothiazine and N-Methyl Phenothiazine
1999Phenothiazine (PhT) (fig. 1) and N-methyl phenothiazine (N-MePhT) are of special interest for their properties as photosensitizer, possible mutagen, and toxicity. Phenothiazine is employed in the preparation of carbazoles, piperazines [1] and charge-transfer semiconducting complexes [2].
J. L. Núñez +3 more
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Phenothiazine in der Kinderchirurgie
Zeitschrift f�r Kinderheilkunde, 1955Durch die Phenothiazine wurde die Behandlung und Verhutung des schweren Schocks und Kollaps in eine neue Richtung gelenkt. Die Chirurgie unterscheidet den Spannungs- und Entspannungskollaps. Die Unterschiede werden aufgezeigt und die spezielle Therapie mit Phenothiazinen besprochen.
Waldemar Ch. Hecker, Helga Berg
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Phenothiazine-Induced Decompensation
Archives of General Psychiatry, 1974Adverse mental reactions to phenothiazines have been anecdotally reported. In a systematic study 80 patients with the diagnosis of schizophrenia received phenothiazines in conventional dosages. Nine patients experienced dramatic exacerbations of psychosis on phenothiazines with a piperazine side group—particularly fluphenazine enanthate.
Theodore Van Putten +2 more
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Sensitivity to a Phenothiazine (Butaperazine)
Canadian Psychiatric Association Journal, 1968A second study of butaperazine on twenty-two patients compared to a previous group of twenty-four patients revealed rather similar results. Twenty of the subjects were involved in both studies, with an eleven-week period off medication in between the two treatment regimes.
Laska E, Simpson Gm
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