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Phenothiazines in Urine

Journal of Mental Science, 1962
Patients in the care of the Department of Psychological Medicine, Guy's Hospital, who are receiving moderate and large doses of phenothiazine drugs are regularly tested for evidence of hepatic or haematological disturbance. In the course of such an investigation, when the urine of a schizophrenic patient was tested with modified Ehrlich's reagent for ...
R. G. Huntsman, P. D. Griffiths, S. Gold
openaire   +3 more sources

Non-directed copper-catalyzed regioselective C-H sulfonylation of phenothiazines.

Organic and biomolecular chemistry, 2019
We develop a simple and general method for sulfonylation of phenothiazines under Cu(i) catalysis. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields.
Caiyan Liu, Yongli Shen, Kedong Yuan
semanticscholar   +1 more source

Mild, Periodate-Mediated, Dehydrogenative C-N Bond Formation with Phenothiazines and Phenols.

Organic Letters, 2016
The dehydrogenative amination of phenols with phenothiazines was achieved in transition-metal-free conditions, utilizing cheap sodium periodate as oxidant, at low temperature.
Rongwei Jin, F. Patureau
semanticscholar   +1 more source

Four-Component Approach to N-Substituted Phenothiazines under Transition-Metal-Free Conditions.

Organic Letters, 2015
An efficient synthesis of N-substituted phenothiazines has been developed from readily available amines, cyclohexanones, and elemental sulfur. The combination use of KI/DMSO in an oxygen atmosphere significantly improved the reaction yields.
Jinjin Chen   +5 more
semanticscholar   +1 more source

The Toxicity of Phenothiazine

Drug Metabolism and Drug Interactions, 1994
Phenothiazine, the parent compound of a multitude of present-day drugs, has been employed on an extensive scale for its insecticidal, fungicidal, antibacterial and anthelmintic properties. Almost a catholicon, its widespread use in animals and man has led to the uncovering of many adverse reactions encompassing effects on blood elements, neuromuscular ...
openaire   +3 more sources

Structures of benzo[a]phenothiazine and benzo[c]phenothiazine

Acta Crystallographica Section C Crystal Structure Communications, 1993
Benzo[a]phenothiazine (I), C 16 H 11 NS, M r =249.3, monoclinic, P2 1 /a, a=25.269 (2), b=23.347 (2), c=8.306 (2) A, β=91.71 (1) o , V=4898 (1) A 3 , Z=16, D m =1.35, D x =1.35 Mg m -3 , λ(Mo Kα)=0.71073 A, μ=0.23 mm -1 , F(000)=2080, T=293 K, R=0.069 for 4248 observed reflections. Benzo[c]phenothiazine (II), C 16 H 11 NS, M r =249.3, monoclinic, P2 1 /
K. Kozawa   +3 more
openaire   +2 more sources

Method for the Synthesis of Phenothiazines via a Domino Iron-Catalyzed C-S/C-N Cross-Coupling Reaction.

Journal of Organic Chemistry, 2015
An environmentally benign and efficient method has been developed for the synthesis of phenothiazines via a tandem iron-catalyzed C-S/C-N cross-coupling reaction.
Weiye Hu, Songlin Zhang
semanticscholar   +1 more source

Phenothiazines as a solution for multidrug resistant tuberculosis: From the origin to present.

International Microbiology, 2015
Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background.
J. Kristiansen   +6 more
semanticscholar   +1 more source

One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction.

Journal of Organic Chemistry, 2015
A novel and efficient synthesis of pyrrolo[3,2,1-kl]phenothiazines has been developed through a Cu(I)-catalyzed tandem C-S coupling/double cyclization process.
Jiaming Tang   +5 more
semanticscholar   +1 more source

The active role of excited states of phenothiazines in photoinduced metal free atom transfer radical polymerization: singlet or triplet excited states?

, 2016
The active role of phenothiazine excited states in photoinduced metal-free atom transfer radical polymerization (ATRP) was investigated by using laser flash photolysis, fluorescence, phosphorescence and electron spin resonance spectroscopy.
S. Jockusch, Y. Yagcı
semanticscholar   +1 more source

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