Results 71 to 80 of about 29,628 (301)

Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins*

Journal of Biological Chemistry, 2005
Tau protein is the major component of the intraneuronal filamentous inclusions that constitute defining neuropathological characteristics of Alzheimer's disease and other tauopathies.
Sayuri Taniguchi, N. Suzuki, Masami Masuda, S. Hisanaga, T. Iwatsubo, M. Goedert, M. Hasegawa   +6 more
semanticscholar   +1 more source

Quantitative Analysis of Fluorescent Sensor Arrays

Analysis &Sensing, Accepted Article.
Fluorescent sensor arrays address the limitations of a single sensor by leveraging multiple sensing elements to generate unique response patterns for each of the analyte of interest. This approach has emerged as a powerful tool for identifying and analysing intricate chemical and biological environments using various multivariate analytical tools such ...
Karandeep Grover, Muhammad Tahir Waseem, Haobo Guo, Elizabeth New   +3 more
wiley   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, EarlyView.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1.

Acta Biochimica Polonica, 2011
Multidrug resistance (MDR) of cancer cells poses a serious obstacle to successful chemotherapy. The overexpression of multispecific ATP-binding cassette transporters appears to be the main mechanism of MDR.
O. Wesołowska
semanticscholar   +1 more source

A Review of the Use of Chemical Stabilisation Methods for Lithium‐Ion Batteries

Battery Energy, EarlyView.
The review reveals that while chemical stabilisation techniques for recycling EOL LIBs are widely used, many studies overlook safety risks, focusing on quick, low‐cost methods. Only a few studies address the associated hazards, highlighting the need for safer, well‐understood stabilisation processes in battery recycling. ABSTRACT The increasing amounts
Mark D. Williams‐Wynn, Marcin H. Durski   +1 more
wiley   +1 more source

Single‐Ion Conductive Bacterial Cellulose Membrane Towards High Performance Lithium‐Oxygen Batteries

Battery Energy, EarlyView.
Bacterial cellulose (BC) is a natural polymer with ultrafine nanofibrous network. BC membrane has excellent affinity to organic electrolyte, high ionic conductivity and inherent ion selectivity, which can transfer lithium ions and suppress the shuttling of anions across the membrane, available for iodide‐assisted lithium‐oxygen batteries (LOBs ...
Aqiang Wu, Mingxing Wang, Yaming Pang, Xinyu Li, Xiangqun Zhuge, Zhihong Luo, Guogang Ren, Kun Luo, Yurong Ren, Dan Liu, Weiwei Lei, Jianwei Lu   +11 more
wiley   +1 more source

Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects

BMC Psychiatry, 2009
Background Although much progress has been made on antipsychotic drug development, precise mechanisms behind the action of typical and atypical antipsychotics are poorly understood.
Song Jonathan, Llenos Ida C, Weis Serge, Higgs Brandon W, Choi Kwang H, Dulay Jeannette R, Yolken Robert H, Webster Maree J   +7 more
doaj   +1 more source

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

Nature Communications, 2020
So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF ...
Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L. Will, Divita Garg, Claudia Sippel, Tobias G. Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler   +14 more
doaj   +1 more source

Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation

Cell Death and Disease, 2011
Chemotherapy resistance poses severe limitations on the efficacy of anti-cancer medications. Recently, the notion of using novel combinations of ‘old’ drugs for new indications has garnered significant interest.
D. Zong, P. Hååg, I. Yakymovych, R. Lewensohn, K. Viktorsson   +4 more
semanticscholar   +1 more source

Catalysis in Chemical Modification of Proteins

ChemCatChem, EarlyView.
Catalytic principles of synthetic organic chemistry have been increasingly applied to chemical modification of proteins during the recent years. This review article describes how seven types of catalytic systems —electrocatalysis, photocatalysis, metal catalysis, acid catalysis, organocatalysis, supramolecular catalysis, and heterogeneous catalysis ...
Seiya Ishizawa, Koki Fujimura, Kounosuke Oisaki, Shinichi Sato, Jun Ohata   +4 more
wiley   +1 more source