Results 131 to 140 of about 2,267,994 (311)

Measuring phenotype-phenotype similarity through the interactome

, 2018
Background Recently, measuring phenotype similarity began to play an important role in disease diagnosis. Researchers have begun to pay attention to develop phenotype similarity measurement.
Weiwei Hui, Jiajie Peng, Xuequn Shang
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Unified Phenotype Ontology : a framework for cross-species integrative phenomics [PDF]

Phenotypic data are critical for understanding biological mechanisms and consequences of genomic variation, and are pivotal for clinical use cases such as disease diagnostics and treatment development.
Wood, V., Bridges, Y, Gehrke, S., Ibrahim, A., Engel, SR, Pilgrim, Clare, Fisher, M., Sollis, E., Fisher, Malcolm, Cuzick, A, Harris, Nomi L, Kohler, S., Segerdell, E, Harris, Laura, Haendel, M. A., Alghamdi, Sarah, Parkinson, Helen, Engel, Stacia R, Jacobsen, Julius OB, Osumi-Sutherland, D, Toro, S, Engel, S. R., de Souza, Vinicius, Mungall, C. J., Callahan, Tiffany J, Carmody, Leigh C, Köhler, Sebastian, McMurry, Julie A, Caron, A. R., McLaughlin, JA, Harris, Midori A, Bello, S. M., Jacobsen, Julius O B, Caufield, H, Bridges, Y., Hansen, P, Pendlington, Zoë M, Harris, NL, Cuzick, A., Sollis, E, Vasilevsky, N., Segerdell, Erik, Jacobsen, JOB, Munoz-Fuentes, V., McLaughlin, James A, Caron, Anita R, Vasilevsky, Nicole, Bello, SM, Sollis, Elliot, Stefancsik, Ray, Anagnostopoulos, A. V., Osumi-Sutherland, D., Pendlington, ZM, Robb, Sofia MC, Robinson, Peter N, Bello, Susan M, Caufield, H., Ibrahim, A, Balhoff, James P, Harris, MA, Stefancsik, R, Balk, M. A., Anagnostopoulos, Anna V, Cuzick, Alayne, Anagnostopoulos, AV, Callahan, TJ, Ibrahim, Arwa, Caufield, Harry, Fey, Petra, Wood, V, Bradford, YM, Balhoff, JP, Fey, P, McLaughlin, J. A., Robb, Sofia M C, Osumi-Sutherland, David, Munoz-Torres, M. C., Matentzoglu, N., Robb, SMC, Hansen, Peter, Harris, L., Alghamdi, SM, Jacobsen, J. O., Balhoff, J. P., Wood, Valerie, Grove, C., Hansen, P., Köhler, S, Toro, S., Carmody, Leigh, Carmody, L. C., Seager, J., Balk, MA, Fisher, M, Toro, Sabrina, Haendel, Melissa A, Gehrke, Sarah, Seager, James, Mungall, CJ, Munoz-Torres, Monica C, Alghamdi, Sarah M, Pendlington, Z. M., Robinson, P. N., Munoz-Fuentes, Violeta, Munoz-Torres, MC, Seager, J, Parkinson, H, Smedley, D, Robinson, PN, Smedley, Damian, Segerdell, E., Robb, S. M., Fey, P., Gehrke, S, Parkinson, H., Alghamdi, S. M., Pilgrim, C., Harris, M. A., Callahan, T. J., Bridges, Yasemin, Smedley, D., McMurry, JA, Bradford, Yvonne M, Souza, V. D., Munoz-Fuentes, V, Bradford, Y. M., Haendel, MA, Carmody, LC, Vasilevsky, N, Harris, L, Pilgrim, C, Matentzoglu, Nicolas, Grove, C, Stefancsik, R., Harris, N. L., Caron, AR, Matentzoglu, N, Balk, Meghan A, de Souza, V, Mungall, Christopher J, McMurry, J. A., Grove, Christian   +141 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Atopy phenotype [PDF]

Thorax, 1998
S Thomas, N Morton, S Holgate
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Maxillary prognathism phenotype.

, 2014
(A) Unaffected phenotype with normal occlusion. (B) Affected phenotype: moderate maxillary prognathism with resulting malloclusion of the incisor teeth (Picture: ISME).
Sylvie Froidevaux (512198), Stefan Rieder (81673), Markus Neuditschko (123577), Christine Flury (164251), Dominik Burger (81671), Christoph Koch (512197), Tosso Leeb (81674), Heidi Signer-Hasler (164244)   +7 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source