Results 121 to 130 of about 2,267,994 (311)
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Example phenotype-classes and binned subphenotypes within phenotype-classes.
, 2013 Presented below are examples of phenotypes binned into three phenotype classes, “Asthma”, “BMI”, and “CRP”. Table S2 contains the complete list of matched phenotypes across studies within phenotype-classes, for all phenotype-classes used within this ...
Charles Kooperberg (18693) +28 more
core +1 more source
DECIPHER : Database of chromosomal imbalance and phenotype in humans using ensembl resources [PDF]
, 2009 Many patients suffering from developmental disorders harbor submicroscopic deletions or duplications that, by affecting the copy number of dosage-sensitive genes or disrupting normal gene expression, lead to disease.
Corpas, M. +11 more
core +1 more source
, 2022 This thesis is centered around the development and application of a digital platform for passive behavioral human subject research.This platform named Behapp (https://behapp.com), developed at the University of Groningen, makes use of mobile ‘apps’ to passively record various attributes related to social and explorative behavior through the smartphones
openaire +2 more sources
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2018 Understanding the genetic relationship of crop ideotypes is essential for genetic analysis and breeding. The objective of this study was to determine genetic differentiation present among 20 selected tepary bean (Phaseolus acutifolius A.
Zinhle Babongile Mhlaba +4 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2019 The aim of the experiments was to evaluate a selection of faba bean (Vicia faba L.) var. minor varieties for further production improvement on the basis of their productivity and phenotype characteristics under the short season of the Northern European ...
Margit Olle +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source