Results 101 to 110 of about 605,923 (256)
New phenotypes for new breeding goals in dairy cattle
Animal, 2012 Cattle production faces new challenges regarding sustainability with its three pillars – economic, societal and environmental. The following three main factors will drive dairy cattle selection in the future: (1) During a long period, intensive selection
D. Boichard, M. Brochard
doaj +1 more source
, 2019 Organisms. Journal of Biological Sciences, V. 3, N. 2 (2019)
Alessio Martino +2 more
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Paraoxonase1 activity and its phenotype in untreated hyperthyroid Malay patients [PDF]
, 2022 Paraoxonase 1 (PON 1) is an enzyme synthesized in the liver and is associated with high density lipoprotein (HDL) in the systemic circulation. It is an antioxidant in which prevents oxidative stress and inflammation.Since oxidative stress had been proven
Yaacob, Najib Majdi +6 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Toward an Objective Characterization of an Anhedonic Phenotype: A Signal-Detection Approach [PDF]
, 2005 Background: Difficulties in defining and characterizing phenotypes has hindered progress in psychiatric genetics and clinical neuroscience. Decreased approach-related behavior and anhedonia (lack of responsiveness to pleasure) are considered cardinal ...
O'Shea, James P. +2 more
core +1 more source
IGDB-DuLab/Single-cell-phenotype-analysis: SCAP
, 2022 This repository contains the source code used in our study titled "Defect-Buffering Cellular Plasticity Increases Robustness of Metazoan Embryogenesis". The provided scripts allow quantification and phenotypic determination of six types of developmental ...
IGDB-DuLab
core +1 more source
Three Ontologies to Define Phenotype Measurement Data
Frontiers in Genetics, 2012 There is an increasing need to integrate phenotype measurement data across studies for both human studies and those involving model organisms. Current practices allow researchers to access only those data involved in a single experiment or multiple ...
Mary eShimoyama +8 more
doaj +1 more source