Results 91 to 100 of about 605,923 (256)

Social cognition in Williams Syndrome: genotype/phenotype insights from partial deletion patients [PDF]

, 2012
Identifying genotype/phenotype relations in human social cognition has been enhanced by the study of Williams syndrome (WS). Indeed, individuals with WS present with a particularly strong social drive, and researchers have sought to link deleted genes in
Kay eMetcalfe, Metcalfe, K., Annette Karmiloff-Smith, Senju, Atsushi, Peter Turnpenny, Wu, Racehl, Longhi, Elena, Happé, Francesca, Kay Metcalfe, Sansbury, F., Hannah Broadbent, Longhi, E, Metcalfe, Kay, Farran, EK, D'Souza, D, Happé, F., Turnpenny, Peter, Annette eKarmiloff-Smith, Wu, Rachel, Elena eLonghi, Longhi, E., Sansbury, Francis, Francesca eHappé, D'Souza, Dean, Farran, Emily, Elena Longhi, Tassabehji, M., Emily K. Farran, Turnpenny, P., Metcalfe, K, Tassabehji, May, Karmiloff-Smith, A, Dean eD'Souza, Broadbent, H., Broadbent, Hannah, Tassabehji, M, Atsushi Senju, Broadbent, H, Francis eSansbury, Rachel Wu, Wu, R, Peter eTurnpenny, May eTassabehji, Happé, F, Farran, E.K., Atsushi eSenju, Francis Sansbury, Turnpenny, P, Dean D’Souza, Francesca Happé, Senju, A, Hannah eBroadbent, Rachel eWu, Sansbury, F, May Tassabehji, Karmiloff-Smith, Annette, Farran, Emily K   +56 more
core   +1 more source

The Integrated Phenotype [PDF]

Integrative and Comparative Biology, 2012
Proper functioning of complex phenotypes requires that multiple traits work together. Examination of relationships among traits within and between complex characters and how they interact to function as a whole organism is critical to advancing our understanding of evolutionary developmental plasticity.
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Challenges of molecular nutrition research 6:the nutritional phenotype database to store, share and evaluate nutritional systems biology studies [PDF]

, 2010
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network ...
Ommen, Ben van, Rocca Serra, P., van Ommen, Ben, Wopereis, Suzan, Saito, J.T., de Groot, P.J., Marijana Radonjic, Mathers, JC, Mathers, John C, Müller, M.R., Evelo, Chris T, Ommen, B., van, Ruan Elliott, Suzan Wopereis, Evelo, CT, Groot, P. de, Evelo, C.T., Drevon, C.A., Mathers, John C., Rocca-Serra, P, Evelo, C.T.A.; id_orcid, Scalbert, A, Saito, J., Lars O. Dragsted, Augustin Scalbert, Saito, J, Anthony Travis, Wopereis, S, Bouwman, Jildau, Kaput, J, Scalbert, A., Ben van Ommen, Travis, A., Michael Müller, Philippe Rocca-Serra, Mueller, M, Elliott, R., Drevon, CA, Dragsted, Lars Ove, Jim Kaput, Bouwman, J., Groot, Philip de, Groot, P.J., de, Müller, M., Ommen, B. van, Drevon, Christian A., Bouwman, J.H., John C. Mathers, Travis, A, Pepping, F., de Groot, P, de Groot, Philip, Dragsted, LO, Kaput, J., Evelo, C.T.A., Elliott, R, Fre Pepping, Elliott, Ruan, Radonjic, Marijana, Radonjic, M., van Ommen, B., Philip de Groot, Jildau Bouwman, Jahn Saito, Rocca-Serra, P., Evelo, Chris T., Dragsted, Lars O, Kaput, Jim, de Groot, P., Pepping, F, Radonjic, M, Bouwman, J, Chris T. Evelo, Wopereis, S., Müller, Michael, Saito, Jahn, Christian A. Drevon, Rocca-Serra, Philippe, Pepping, Fre, Travis, Anthony, Drevon, Christian A, Evelo, C., Scalbert, Augustin, Mathers, J.C., Dragsted, Lars O., Dragsted, L.O., van Ommen, B   +86 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Offspring phenotype is shaped by the non-sperm fraction of semen

, 2021
In a large majority of animal species, the only contribution of males to the next generation has been assumed to be their genes (sperm). However, along with sperm, seminal plasma contains a wide array of extracellular factors that have many important ...
Huuskonen, Hannu,University of Eastern Finland, Kekäläinen, Jukka,University of Eastern Finland, Jokiniemi, Annalaura,University of Eastern Finland, Janhunen, Matti,Natural Resources Institute Finland   +3 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Phenotype-related genes in MIP101 clone 8 cells with CEA over-expression.

, 2016
Phenotype-related genes in MIP101 clone 8 cells with CEA over-expression.
Stephen J. O’Brien (108646), Olga Bajenova (3095223), Alexander Shishkin (3095226), Anna Gorbunova (3095211), Ekaterina Bozhokina (3095214), Igor Evsyukov (3095229), Michael Rayko (3095220), Svetlana Gapon (3095217)   +7 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Fetal akinesia deformation sequence with pontocerebellar hypoplasia, and migration and gyration defects

Autopsy and Case Reports, 2021
Fetal akinesia deformation sequence (FADS), or Pena-Shokeir phenotype is a constellation of deformational changes resulting from decreased or absent fetal movement, and include arthrogryposis, and craniofacial and central nervous system anomalies.
Meghan Elizabeth Kapp, Pamela Lyle, Hilary Highfield Nickols   +2 more
doaj