Results 81 to 90 of about 605,923 (256)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Cohen syndrome due to a novel VPS13B mutation in a Chinese family

Journal of Neurorestoratology, 2022
We present the case of a novel homozygous nonsense (c.4846C > T [p.R1616X]) mutation in the VPS13B in a Chinese boy with the primary symptoms of Cohen syndrome.
Shu-ying Cai, Pei Li, Shu-xiang Hu, Hui-qiang Cai, Wen-jie Li, Gui-lan Peng   +5 more
doaj   +1 more source

Phenotyping bleeding [PDF]

Current Opinion in Hematology, 2012
Although recorded evidence of phenotyping bleeding disorders extends back two millennia, standardization of phenotyping has only begun in the past half century. This was spurred by the need for greater precision in diagnosing disorders in order to select proper laboratory tests and treatment, and the realization that the bleeding history provides ...
Paula, James, Barry S, Coller
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Using the community-based breeding program (CBBP) model as a collaborative platform to develop the African Goat Improvement Network—Image collection protocol (AGIN-ICP) with mobile technology for data collection and management of livestock phenotypes

Frontiers in Genetics, 2023
Introduction: The African Goat Improvement Network Image Collection Protocol (AGIN-ICP) is an accessible, easy to use, low-cost procedure to collect phenotypic data via digital images.
M. Jennifer Woodward-Greene, M. Jennifer Woodward-Greene, M. Jennifer Woodward-Greene, Jason M. Kinser, Heather J. Huson, Tad S. Sonstegard, Johann Soelkner, Iosif I. Vaisman, Paul Boettcher, Clet W. Masiga, Christopher Mukasa, Solomon Abegaz, Morris Agaba, Sahar S. Ahmed, Oliver F. Maminiaina, Tesfaye Getachew, Timothy N. Gondwe, Aynalem Haile, Yassir Hassan, Absolomon Kihara, Aly Kouriba, Hassan A. Mruttu, Denis Mujibi, Wilson Nandolo, Barbara A. Rischkowsky, Benjamin D. Rosen, Brian Sayre, Maria Taela, Curtis P. Van Tassell   +28 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Elucidation of the role of glutamine synthetase seed isoform GLN1;5 in Arabidopsis thaliana (L.) with a reverse genetics approach [PDF]

Archives of Biological Sciences, 2019
Glutamine synthetase (E.C. 6.3.1.2) is a key enzyme of plant nitrogen metabolism that assimilates ammonia into glutamine. The Arabidopsis thaliana genome encodes one chloroplastic (GLN2) and five cytosolic (GLN1;1 – GLN1;5) isoforms with different ...
Dragićević Milan B., Ćuković Katarina B., Zdravković-Korać Snežana R., Simonović Ana D., Bogdanović Milica D., Todorović Slađana I.   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition [PDF]

, 2011
Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or by ...
Burdge, GC, Karen A Lillycrop, Lillycrop, KA, Samuel P Hoile, Peter D Gluckman, Karen A. Lillycrop, Graham C. Burdge, Hoile, SP, Hanson, MA, Peter D. Gluckman, Lillycrop, Karen A., Nicola A. Thomas, Hoile, Samuel P., Thomas, Nicola A., Nicola A Thomas, Gluckman, PD, Burdge, Graham C., Mark A Hanson, Graham C Burdge, Uller, T, Tobias Uller, Samuel P. Hoile, Thomas, NA, Uller, Tobias, Hanson, Mark A., Mark A. Hanson, Gluckman, Peter D.   +26 more
core   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source