Results 61 to 70 of about 2,267,994 (311)

Systemic genome-epigenome analysis captures a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma

Molecular Systems Biology
Gastrointestinal adenocarcinoma is a major cancer type for the digestive system, ranking as the top cause of cancer-related deaths worldwide. While there has been extensive research on mutations in protein-coding regions, the knowledge of the landscape ...
Fuyuan Li, Shangzi Wang, Lian Chen, Ning Jiang, Xingdong Chen, Jin Li   +5 more
doaj   +1 more source

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning

Clinical and Developmental Immunology, 2010
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT).
Behnam Sadeghi, Suleiman Al-Hashmi, Zuzana Hassan, Bjorn Rozell, Hernan Concha, Carin Lundmark, Kjell-Olov Grönvik, Manuchehr Abedi-Valugerdi, Moustapha Hassan   +8 more
doaj   +1 more source

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

Frontiers in Immunology, 2021
Tissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic
Chunye Zhang, Ming Yang, Aaron C. Ericsson, Aaron C. Ericsson, Aaron C. Ericsson   +4 more
doaj   +1 more source

A worldwide correlation of lactase persistence phenotype and genotypes [PDF]

, 2010
Background: The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Jones Bryony L, Ingram, C.J.E., Thomas, M.G., Swallow Dallas M, Jones, B.L., Dallas M Swallow, Itan, Y., Yuval Itan, Swallow, D.M., Itan Yuval, Thomas Mark G, Catherine JE Ingram, Ingram Catherine JE, Bryony L Jones, Mark G Thomas   +14 more
core   +1 more source

LEFT VENTRICULAR REMODELING IN HEART FAILURE (PART ІI): PHENOTYPIC HETEROGENEITY AS A RATIONALE FOR PERSONALIZED PATIENTS` MANAGEMENT

Клінічна та профілактична медицина, 2023
Aim: to provide a literature review of the current conсepts on phenotypic heterogeneity of left ventricular (LV) remodeling in heart failure (HF), and highlight the significance of such a diversity for an implementation of personalized patients ...
T.Ya. Chursina, A.M. Kravchenko, K.O. Mikhaliev   +2 more
doaj   +1 more source

Asthma Phenotypes

Seminars in Respiratory and Critical Care Medicine, 2012
The identification of phenotypes of asthma has a long history, but previous classifications have not identified clinically important differences in pathology, natural history, or treatment response. Progress has accelerated recently, fueled by the development of new techniques to assess airway disease, particularly noninvasive techniques to assess ...
openaire   +3 more sources

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

stephanieherman/MS-phenotype-prediction: v1.0.0

, 2023
This release contains the code that was used to generate the results presented in the article Disease phenotype prediction in multiple sclerosis. The analysis workflow consists of three main components: The data processing, where data is cleaned and ...
Stephanie Herman, Staffan Arvidsson McShane   +1 more
core   +1 more source

Quantitative dissection of sexual dimorphism in mice through Y-linked gene knockouts and multivariate phenotyping

Scientific Reports
Sexual dimorphism (SDM) is regulated by sex chromosomes, yet the specific contribution of individual genes remains unclear. To address this, we conducted a comprehensive phenotyping analysis to investigate the roles of Y chromosome-linked genes in SDM ...
Nobuhiko Tanaka, Kento Miura, Ai Ozaki, Yasuyo Kozawa, Masaru Tamura, Atsuo Ogura, Shogo Matoba   +6 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source