Results 231 to 240 of about 2,909,871 (334)

Intermediate phenotype

Folia Pharmacologica Japonica, 2013
openaire   +3 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Comparative analysis of hormonal and metabolic indices in phenotypic subgroups of polycystic ovary syndrome. [PDF]

J Turk Ger Gynecol Assoc
Savran Üçok B, Dikici Aktaş T, Özalp E, Ulusoy CO, Akbulut ÖV, Kından A, Fıratlıgil FB.   +6 more
europepmc   +1 more source

Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes

, 2019
Yo-Han Han, Jeong-Geon Mun, Hee Dong Jeon, Jin Bong Park, Ji-Ye Kee, Seung‐Heon Hong   +5 more
openalex   +1 more source

Data from Intracellular Bacterial Vectors That Induce CD8⁺ T Cells with Similar Cytolytic Abilities but Disparate Memory Phenotypes Provide Contrasting Tumor Protection

, 2023
Felicity C. Stark, Subash Sad, Lakshmi Krishnan   +2 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Golden leaf formation of Populus nigra is associated with the up-regulation of Stay-Green expression. [PDF]

Mol Hortic
Fu W, Li Z, Zhai X, Zhang H, Feng S, Zhou A.   +5 more
europepmc   +1 more source

Data from Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

, 2023
Bohai Feng, Ying Shen, Xavier Pastor Hostench, Matthias Bieg, Michaela Plath, Naveed Ishaque, Roland Eils, Kolja Freier, Wilko Weichert, Karim Zaoui, Jochen Heß   +10 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Table S4 from Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation

Christopher Carroll, Auraya Manaprasertsak, Arthur Boffelli Castro, Hilda van den Bos, Diana C.J. Spierings, René Wardenaar, Anuraag Bukkuri, Niklas Engström, Etienne Baratchart, Minjun Yang, Andrea Biloglav, Charlie K. Cornwallis, Bertil Johansson, Catharina Hagerling, Marie Arsenian‐Henriksson, Kajsa Paulsson, Sarah R. Amend, Sofie Mohlin, Floris Foijer, Alan McIntyre, Kenneth J. Pienta, Emma U. Hammarlund   +21 more
openalex   +1 more source