Results 261 to 270 of about 3,800,975 (380)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Bone Phenotype in Autosomal Dominant Polycystic Kidney Disease. [PDF]

Calcif Tissue Int
Jankowska M, Magnusson P, Debowska M, Lindholm B, Qureshi AR, Lukaszuk T, Dębska-Ślizień A, Fuster DG, Stenvinkel P, Haarhaus M.   +9 more
europepmc   +1 more source

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.

Cell Metabolism, 2016
Christopher D. Wiley, Michael C. Velarde, Pacome Lecot, Su Liu, E. A. Sarnoski, Adam Freund, Kotaro Shirakawa, H. Lim, Sonnet S. Davis, A. Ramanathan, A. Gerencser, E. Verdin, J. Campisi   +12 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The Double-High Phenotype: Synergistic Impact of Metabolic and Arterial Load on Ambulatory Blood Pressure Instability. [PDF]

J Clin Med
Yilmaz A, Eyiol A.
europepmc   +1 more source

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

, 2018
Shanhang Jia, Mark T. Miedel, Marilyn Ngo, Ryan Hessenius, Ning Chen, Peilu Wang, Amir Bahreini, Zheqi Li, Zhijie Ding, Tong Ying Shun, Daniel M. Zuckerman, D. Lansing Taylor, Shannon L. Puhalla, Adrian V. Lee, Steffi Oesterreich, Andrew M. Stern   +15 more
openalex   +2 more sources

Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients [PDF]

, 2018
Danielle Sample, N. Jewel Samadder, Lisa M. Pappas, Kenneth M. Boucher, Wade S. Samowitz, Therese Berry, Michelle Westover, Deepika Nathan, Priyanka Kanth, Kathryn R. Byrne, Randall W. Burt, Deborah W. Neklason   +11 more
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

PERADIGM: Phenotype embedding similarity-based rare disease gene mapping. [PDF]

PLoS Genet
Zheng W, Xie Y, Gu J, Li H, Somlo S, Besse W, Zhao H.   +6 more
europepmc   +1 more source

Soft windowing application to improve analysis of high-throughput phenotyping data [PDF]

, 2019
Hamed Haselimashhadi, Jeremy Mason, Violeta Muñoz‐Fuentes, Federico López, Kola Babalola, Elif F. Acar, Vivek Kumar, Jacqui White, Ann M. Flenniken, Ruairidh King, Ewan Straiton, John R. Seavitt, Angelina Gaspero, Arturo Garza, Audrey E. Christianson, Chih‐Wei Hsu, Corey Reynolds, Denise G. Lanza, Isabel Lorenzo, Jennie R. Green, Juan Gallegos, Ritu Bohat, Rodney C. Samaco, Surabi Veeraragavan, Jong Kim, Gregor Miller, Helmult Fuchs, Lillian Garrett, Lore Becker, Yeon Kyung Kang, David Clary, Soo Young Cho, Masaru Tamura, Nobuhiko Tanaka, Kyung Dong Soo, Alexandr Bezginov, Ghina Bou About, Marie‐France Champy, Laurent Vasseur, Sophie Leblanc, Hamid Méziane, Mohammed Selloum, Patrick T. Reilly, Nadine Spielmann, Holger Maier, Valérie Gailus‐Durner, Tania Sorg, Hiroshi Masuya, Yuichi Obata, Jason D. Heaney, Mary E. Dickinson, Wurst Wolfgang, Glauco P. Tocchini‐Valentini, K. C. Kent Lloyd, Colin McKerlie, Je Kyung Seong, Yann Hérault, Martin Hrabě de Angelis, Steve D M Brown, Damian Smedley, Paul Flicek, Ann‐Marie Mallon, Helen Parkinson, Terrence F. Meehan   +63 more
openalex   +1 more source