Results 301 to 310 of about 3,800,975 (380)

Comprehensive analysis of two hotspot codons in the TUBB4B gene and associated phenotypes [PDF]

Jan-Philipp Bodenbender, Valerio Marino, Julia Philipp, Anke Tropitzsch, Christoph Kernstock, Katarína Štingl, Melanie Kempf, Tobias B. Haack, Theresia Zuleger, Pascale Mazzola, Susanne Kohl, Nicole Weisschuh, Daniele Dell’Orco, Laura Kühlewein   +13 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The excess body fat is a potential mediator between consumption of ultra-processed foods and cardiometabolic risk in normal-weight Brazilian children. [PDF]

Front Nutr
Cota BC, Juvanhol LL, Filgueiras MS, Pereira PF, de Novaes JF.   +4 more
europepmc   +1 more source

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

Journal of Clinical Investigation, 2013
T. Tchkonia, Yi Zhu, J. V. van Deursen, J. Campisi, J. Kirkland   +4 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Macrophages on demand: How tissue trauma shapes their role. [PDF]

Eur J Trauma Emerg Surg
Johnsen Stefani L, Wohlgemuth S, Schütte L, Halbgebauer R, Bergmann CB, Huber-Lang M, Wohlgemuth L.   +6 more
europepmc   +1 more source

A Computable Phenotype for Acute Respiratory Distress Syndrome Using Natural Language Processing and Machine Learning.

, 2018
Majid Afshar, Cara Joyce, Anthony Oakey, Perry Formanek, Philip Yang, Matthew M. Churpek, Richard Cooper, Susan Zelisko, Ron Price, Dmitriy Dligach   +9 more
openalex   +1 more source

Hypertriglyceridemic waist phenotype in primary health care: comparison of two cutoff points

, 2017
Marina Augusta Dias Braz, Jallyne Nunes Vieira, Flayane Oliveira Gomes, Priscilla Rafaella da Silva, Ohanna Thays de Medeiros Santos, Ilanna Marques Gomes da Rocha, Iasmin Matias de Sousa, Ana Paula Trussardi Fayh   +7 more
openalex   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source