Results 141 to 150 of about 340,700 (262)

Phenotypes comprehensively [PDF]

Cytometry Part A, 2021
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Phenotypes and Lung Microbiota Signatures of Immunocompromised Patients with Pneumonia-Related Acute Respiratory Distress Syndrome

Yan Hu,1,* Jiawei Shen,2,* Youzhong An,2 Yanwen Jiang,1 Huiying Zhao2 1Department of Respiratory and Critical Care Medicine, Peking University International Hospital, Beijing, People’s Republic of China; 2Department of Critical Care Medicine ...
Jiang Y, Shen J, Hu Y, An Y, Zhao H
core  

ontophylo: Reconstructing the evolutionary dynamics of phenomes using new ontology‐informed phylogenetic methods

Methods in Ecology and Evolution
Reconstructing ancestral states for discrete characters is essential for understanding trait evolution in organisms. However, most existing methods are limited to individual characters and often overlook the hierarchical and interactive nature of traits.
Diego S. Porto, Josef Uyeda, István Mikó, Sergei Tarasov   +3 more
doaj   +1 more source

Decoding Early Clues: Immune Mechanisms, Prevention, Diagnosis, and Treatment of IgE-Mediated Peanut and Tree Nut Allergy in Children

Biomedicines
The rising prevalence of food allergies, particularly to peanuts and tree nuts, poses significant challenges for pediatric health worldwide. These allergens are among the leading causes of severe allergic reactions, including anaphylaxis, often ...
Karolina Dumycz, Agnieszka Szczukocka, Maria Wawszczak, Katarzyna Grzela, Wojciech Feleszko, Marek Kulus   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Clinical phenotypes of COPD and health-related quality of life: a cross-sectional study

, 2019
Chee-Shee Chai,1 Chong-Kin Liam,2 Yong-Kek Pang,2 Diana Leh-Ching Ng,1 Seng-Beng Tan,2 Tat-Seng Wong,2 Jo-Ee Sia2 1Department of Medicine, Faculty of Medicine and Health Science, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia; 2Department of ...
Liam CK, Ng DLC, Chai CS, Sia JE, Wong TS, Pang YK, Tan SB   +6 more
core  

MICROVASCULAR BED CHARACTERISTICS IN A CHILD WITH SEVERE UNCONTROLLED BRONCHIAL ASTHMA: A CASE REPORT AND LITERATURE REVIEW

Паёми Сино
As per available data, pediatric bronchial asthma (BA) is classified into four categories: atopic/allergic (80.2%), unspecified (17.4%), mixed (2.1%), and non-allergic/non-atopic BA (0.3%).
Khurgaeva Anastasia Eduardovna, Gutyrchik Tatyana Aleksandrovna, Gitinov Shamil Abdulvakhidovich, Malakhov Aleksandr Borisovich, Brunova Olga Yurievna, Berezhanskiy Pavel Vyacheslavovich   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Integrating leaf scaled spectra and machine learning for rapid estimation of photosynthetic phenotypes across soybean genotypes

Photosynthesis is central to crop productivity and global carbon dynamics, yet traditional methods for evaluating photosynthetic capacity are slow, low-throughput, and difficult to scale.
Yan, X., Chen, X., Zhang, X., Zhao, Y., Bai, Y., Rickard, W., Feng, M., Qiao, X., Wang, C., Li, F., Yang, W., Guo, X., Yang, C., Zhang, J.   +13 more
core   +1 more source