Results 261 to 270 of about 164,403 (310)

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

open access: yesAdvanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su   +10 more
wiley   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason   +12 more
wiley   +1 more source

Integrative multi-trait phenotyping reveals coordinated root and antioxidant responses underlying drought tolerance in soybean. [PDF]

open access: yesBMC Plant Biol
Zhang C   +12 more
europepmc   +1 more source

Evaluating phenotypic plasticity of reproductive traits among Korean rice cultivars under diverse climatic conditions. [PDF]

open access: yesFront Plant Sci
Hong JK   +8 more
europepmc   +1 more source

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