Results 101 to 110 of about 4,546,004 (334)

Comparison of Genotypic and Phenotypic Correlations: Cheverud’s Conjecture in Humans

Genetics, 2018
Cheverud’s conjecture asserts that the use of phenotypic correlations as proxies for genetic correlations in situations where genetic data is not available is appropriate. Although empirical evidence for this has been found across...
Sebastian M. Sodini, K. Kemper, N. Wray, M. Trzaskowski   +3 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

YKL-40 correlates with the phenotype of asthma [PDF]

World Allergy Organization Journal, 2015
Background YKL-40 is a chitinase-like protein synthesized by human macrophages, monocytes, and neutrophils. Although it is not specific, YKL-40 has been shown to correlate with asthma, its severity and level of control. As asthma is heterogeneous, it would be useful to determine whether the marker’s levels correlate with phenotypes of the disease.
Krzysztof Specjalski, Ewa Jassem
openaire   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Genetic Variation, Heritability, Phenotypic and Genotypic Correlation Studies for Yield and Yield Components in Promising Barley Genotypes

, 2011
Eighty six promising new barley genotypes and three checks including one indigenous cultivar (Hordeum vulgare L. var Rum) were grown in two successive seasons of 2005 and 2006 to assess the presence of variability for desired traits and amount of ...
Jalal A. Al-Tabbal, A. H. Al-Fraihat
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.

American Journal of Human Genetics, 2002
Noonan syndrome (NS) is a developmental disorder characterized by facial dysmorphia, short stature, cardiac defects, and skeletal malformations. We recently demonstrated that mutations in PTPN11, the gene encoding the non-receptor-type protein tyrosine ...
M. Tartaglia, K. Kalidas, A. Shaw, Xiaoling Song, D. Musat, I. van der Burgt, H. Brunner, D. Bertola, A. Crosby, A. Ion, R. Kucherlapati, S. Jeffery, M. Patton, B. Gelb   +13 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Estimation of Phenotypic and Genotypic Correlation Analysis in F3 Populations of Bread Wheat Genotypes

Turkish Journal of Agriculture: Food Science and Technology
Wheat is one of the most important crops all over the world in terms of yield, production, consumption, cultivation, and adoptability. Wheat genotypes exhibiting different yield associated traits which influence each other in many ways.
Akbar Ali, Mansoor Javed Momand, Muhammad Ali, Saeed Ur Rahman, Salman Abbas   +4 more
doaj   +1 more source