Results 111 to 120 of about 8,412,468 (340)

Correlation between Genotypic and Phenotypic Testing for Resistance to Rifampin in Mycobacterium tuberculosis Clinical Isolates in Haiti: Investigation of Cases with Discrepant Susceptibility Results

PLoS ONE, 2014
The World Health Organization has recommended use of molecular-based tests MTBDRplus and GeneXpert MTB/RIF to diagnose multidrug-resistant tuberculosis in developing and high-burden countries.
O. Ocheretina, V. Escuyer, M. Mabou, Gertrude Royal-Mardi, Sean E. Collins, S. Vilbrun, J. Pape, D. Fitzgerald   +7 more
semanticscholar   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

European Respiratory Journal, 2017
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence.
P. Miotto, B. Tessema, E. Tagliani, L. Chindelevitch, A. Starks, C. Emerson, D. Hanna, P. Kim, R. Liwski, M. Zignol, C. Gilpin, S. Niemann, C. Denkinger, Joy Fleming, R. Warren, D. Crook, J. Posey, S. Gagneux, S. Hoffner, C. Rodrigues, I. Comas, D. Engelthaler, M. Murray, D. Alland, L. Rigouts, C. Lange, K. Dheda, R. Hasan, U. D. Ranganathan, R. McNerney, M. Ezewudo, D. Cirillo, M. Schito, C. Köser, T. Rodwell   +34 more
semanticscholar   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Relationships among Yield Components and Selection Criteria for Seed Yield Improvement in Bush Bean (Phaseolus vulgaris L.)

Journal of Agricultural Sciences, 2012
The aim of this research is to determine the relationship among yield and some yield components of dry bean using correlation and path coefficient analysis. The experiment was carried out in irrigated conditions during 2004-2005 and 2005-2006 at the East
Haluk Kulaz, Vahdettin Çiftçi
doaj  

Genetic Variability and Selection of Doubled Haploid Lines of Eggplant (Solanum melongena L.) Obtained from Anther Culture

Agriculture
Genetic variability is essential for accelerating the selection of high-yield varieties. Therefore, this study aims to evaluate the genetic variability and agronomic performance of eggplant doubled haploid obtained through anther culture.
Ma’arif Samsul, Purwoko Bambang Sapta, Ritonga Arya Widura, Dewi Iswari Saraswati   +3 more
doaj   +1 more source

Genetic parameters estimates for milk, fat and protein yield analyzed by test day models for Murrah buffaloes in Brazil

Italian Journal of Animal Science, 2010
The objectives of this study were to estimate genetic parameters for testday milk, fat and protein yields, in Murrah buffaloes. In this study 4,757 complete lactations of Murrah buffaloes were analyzed.
A. Bignardi, H. Tonhati, L. Seno, R. Sesana, A. Tanaka, L. Albuquerque, R. Aspilcueta-Borquis   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Correlation of heterosis with genetic and phenotypic distances.

, 2019
(A) Correlation between pairwise genetic distances between parental accessions and observed heterosis of growth rate in hybrids (n = 368). (B) Correlation between pairwise phenotypic distances between parental accessions (absolute difference in M) and ...
Detlef Weigel (54320), François Vasseur (630171), Dominique de Vienne (39563), Thibault Nidelet (3240648), Cyrille Violle (3244686), Louise Fouqueau (6630932)   +5 more
core   +1 more source