Results 111 to 120 of about 536,745 (332)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Associations between metabolic rate and personality in a free-living small mammal are driven by date of birth

Royal Society Open Science
Physiological states are often regarded as drivers of personality differences, although the causal link between them remains unclear. Studies focusing on energy metabolism often report inconsistent associations with personality traits.
Jingyu Qiu, Carsten Schradin, Astolfo Mata, Neville Pillay, Heiko Rödel   +4 more
doaj   +1 more source

The Cyp2b6 Gene Polymorphism and Phenotypic Correlation of Efavirenz-Based Combination Therapy Among the Niger Delta Ethnic Population: Implications in Modern Pharmacogenomics. [PDF]

Pharmgenomics Pers Med, 2022
Bunu SJ, Owaba ADC, Vaikosen EN, Ebeshi BU.   +3 more
europepmc   +1 more source

Bayesian analysis of the linear reaction norm model with unknown covariate [PDF]

, 2006
The reaction norm model is becoming a popular approach for the analysis of G x E interactions. In a classical reaction norm model, the expression of a genotype in different environments is described as a linear function (a reaction norm) of an ...
Jensen, J., Korsgaard, I.R., Lund, M.S., Madsen, P., Su, G., Sørensen, D.   +5 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Individual variation and repeatability of methane production from dairy cows estimated by the CO2 method in automatic milking system

Animal, 2015
The objectives of this study were to investigate the individual variation, repeatability and correlation of methane (CH4) production from dairy cows measured during 2 different years. A total of 21 dairy cows with an average BW of 619±14.2 kg and average
M.N. Haque, C. Cornou, J. Madsen
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Evaluation and optimal utilisation of the international linear type classification schemes [PDF]

, 2007
End of project reportThe authors would like to acknowledge the Irish Cattle Breeding Federation for access to their excellent database for use in this study and to the Irish Holstein-Friesian Association for financial support of this studyThe main ...
Berry, Donagh
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Relationship Between Hygienic Behavior and Varroa destructor Mites in Colonies Producing Honey or Royal Jelly

Sociobiology, 2014
Genetic and phenotypic parameters for hygienic behavior, invasion and infestation rates, total and effective reproduction of Varroa destructor in Africanized honeybee colonies producing honey (20 hives) or royal jelly (30 mini-hives) were analyzed.
Maria Claudia Colla Ruvolo-Takasusuki, Vagner Alencar Toledo, Denise Alves Lopes   +2 more
doaj   +1 more source