Results 91 to 100 of about 2,617,089 (305)
Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig +10 morewiley +1 more sourceLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more sourceStudy on Phenotypic Variation in Wild Populations of Prunella vulgaris
HorticulturaeObjective: This study aimed to clarify the variation law of phenotypic traits such as the stem, leaf, flower, main branch ear and seed of Prunella vulgaris Linnaeus. (P.Xiaoyu Wu, Shasha Wang, Fangming Liu, Xinhua Zhou, Hui Huang, Qiupeng Yuan, Chao Miao, Yi Yang, Wenwen Zhong, Zuwei Hu, Chen Chen, Yaokun Zhou, Zhi Li +12 moredoaj +1 more sourceThe Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen +6 morewiley +1 more sourceIdentification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping [PDF]
, 2011 The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits.Derrien, Thomas, Tove Fall, Battaille, Géraldine, Lequarre, Anne Sophie, Ratnakumar, Abhirami, Quilez, Javier, Vaysse Amaury, Eija H. Seppälä, Hansen, Mark, H., Lawley, Cindy T, Hannes Lohi, Ahonen, Saija, Seppälä Eija H., Sundberg, Katarina, Webster, Matthew Thomas,, Matthew T Webster, Hedhammar, A., Francis Galibert, Carles Vilà, Sargan, David, Farnir, Frédéric, Snaevar Sigurdsson, Hansson, Jeanette, Kyöstilä, Kaisa, Höglund, Katja, Rosengren Pielberg, Gerli, Lawley, C.T., Rothwell, Simon, Meadows, Jennifer, Kerstin Lindblad-Toh, Lathrop, Mark, null null, Galibert Francis, Hansen Mark S. T., Copeland-Stephenson, Hannah, Karlsson, E K, Aguirre-Hernandez, Jesus, Lindblad-Toh Kerstin, Galibert, Francis, Kierczak, Marcin, Catherine André, Karlsson, Elinor, K., Dukes-McEwan, Joanna, Philipp, Ute, Axelsson Erik, Millar, Kate, Vaysse, A., Owczarek-Lipska, Marta, Elinor K. Karlsson, Axelsson, Erik, Hansen, Mark S. T., Barrio, Álvaro Martínez, Seppälä, E.H., Fall, Tove, Bannasch, Danika, Melin, Malin, Rosengren Pielberg, G, Georges, Michel, Storengen, Linn Mari, Cindy T. Lawley, Wolf, Johanna, Kämpe, Olle, Peeters, Dominique, Gouni, Vassiliki, Bannasch, D, Andersson, Göran, Ake Hedhammar, Fieten, Hille, Dahlgren, Stina, Jens Häggström, Sigurdsson, Snaevar, Lingaas, Frode, Karlsson, Elinor K., Sigurdsson Snaevar, Sigurdsson, S., Hytönen, Marjo, Mogensen, Mette Sloth, Thomas, Anne, Lindblad-Toh, Kerstin, Massey, Jonathan, Axelsson, E., Momozawa, Yukihide, Sigurdsson, S, Fredholm Merete, Hansen, Mark S T, Danika Bannasch, Fall, Tove,, Pamplona, Marilou Ramos, Häggström, J, Rosengren Pielberg, Gerli,, Seppälä, E H, Vilà, Carles, Ratnakumar, A, Abhirami Ratnakumar, Lohi Hannes, Ahlgren, Kerstin, Vilà, Carles, Webster, M T, Erik Axelsson, Leegwater, Peter, Starkey, Mike, Quinnell, Rupert J, Mark S. T. Hansen, Derrien Thomas, Axelsson, Erik,, Andersson, Leif, Björnerfeldt, Susanne, Lohi, Hannes, Mark S T Hansen, Bannasch Danika, Leeb, Tosso, Ratnakumar Abhirami, Karlsson Elinor K., Karlsson, Elinor, LUPA Consortium, Boerkamp, Kim, Pielberg, Gerli Rosengren, Bannasch, Danika L., Hendricks, Anke, Ratnakumar, A., Webster, M.T., Derrien, T, Van Steenbeek, Frank, Hansen, M.S.T., Vaysse, Amaury, Faust, Nathalie, Häggström Jens, Hedhammar, A, Arendt, Maja, Bannasch, D., Vilà, C, Ratnakumar, Abhirami,, Elinor K, André, Catherine, Courtay-Cahen, Celine, Lohi, H., Eija H Seppälä, Elinor K Karlsson, Matthew T. Webster, Clercx, Cécile, Zelenika, Diana, Karlsson, Elinor K, Häggström, Jens, Bonastre, Armand Sánchez, Pielberg, G.R., Karlsson, E.K., Vaysse, A, Galibert, F., Webster, Matthew Thomas, Lohi, H, Hansen, M S, Hitte, C., Vaysse, Amaury, Hansen, Mark S.T., Hitte Christophe, Rutteman, Gerard, Hitte, Christophe, Lawley, C T, Wiik, Caroline, Fall, T, Ollier, William, André Catherine, Fredholm, M., Lawley, Cindy, T., Thomas Derrien, Cindy T Lawley, André, C, Boland, Anne, Lawley, Cindy T., Madsen, Majbritt Busk, Vilà Carles, Druet, Tom, Gerli Rosengren Pielberg, Lindblad-Toh, K, Christophe Hitte, Rosengren Pielberg Gerli, Nevalainen, Elisa, Amaury Vaysse, Fall Tove, Nolan, Catherine, Tengvall, Katarina, Callanan, Sean, Webster Matthew T., Seppälä, Eija H., Ljungvall, Ingrid, Johansson, Cecilia, Fredholm, Merete, Derrien, T., Lindblad-Toh, Kerstin,, Gustafsson, Susanne, Axelsson, E, Merveille, Anne Christine, Fall, T., Haggstrom, J., Mellersh, Cathryn, Webster, Matthew T., Webster, Matthew, T., Lawley Cindy T., Andre, C., Tiret, Laurent, Kennedy, Lorna; id_orcid, Hansen, M.S., Favrot, Claude, Seppälä, Eija, H., Hedhammar, Åke, Galibert, F, Chetboul, Valérie, Merete Fredholm, Hitte, C, Fredholm, M, Carlborg, Örjan, Wess, Gerhard, Catchpole, Brian, Lindblad-Toh, Kerstin, Seppälä, Eija H, Hedhammar Åke, Hansen, Mark,, Karlsson, Elinor,, Webster, Matthew,, Hansen, MST, Häggström, Jens,, Lawley, Cindy,, Lawley, CT, Seppälä, Eija,, Sveriges lantbruksuniversitet., Hedhammar, Åke,, Fall, T,, Pielberg, GR, Seppala, EH, André, Catherine,, Sigurdsson, Snaevar,, Hitte, Christophe,, The Lupa Consortium +232 morecore +1 more sourcePhenotypic variation in urban environments: mechanisms and implications
, 2022 In the past decade, numerous studies have explored how urbanisation affects the mean phenotypes of populations, but it remains unknown how urbanisation impacts phenotypic variation, a key target of selection that shapes, and is shaped by, eco ...Réale, Denis, Charmantier, Anne, Réale, D., Dominoni, Davide, Charmantier, A., Thompson, Megan, J., Dominoni, D.M., Thompson, M.J., Capilla-Lasheras, P., Capilla‐lasheras, Pablo, P. Capilla-Lasheras, D. Réale, A. Charmantier, M.J. Thompson, D.M. Dominoni +14 morecore +1 more sourceRNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira +2 morewiley +1 more sourceGenetic diversity analysis of angled luffa germplasm resources based on phenotypic traits and resequencing data
Frontiers in Plant ScienceIntroductionPhenotypic evaluation and whole-genome resequencing (WGR) techniques play critical roles in the identification and utilization of crop germplasm resources.Zheng Zeng, Li Zhang, Yuanyuan Guo, Yang Li, Qin Chen, Huanzong Song, Jieling Deng, Xiaoyan Sun, Guijun Su, Xinxin He, Dexian Kang, Zhendong Chen +11 moredoaj +1 more source
