Results 101 to 110 of about 2,617,089 (305)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Phenotypic variation among Phytophthora ramorum isolates from California and Oregon [PDF]
, 2006 To manage and control Phytophthora ramorum successfully, it is important to know the amount of phenotypic variation within a given pathogen population.
Miles, L. +4 more
core
Phenotypic variation between siblings with Metachromatic Leukodystrophy
Orphanet Journal of Rare Diseases, 2019 Background Metachromatic Leukodystrophy (MLD) is a rare autosomal-recessive lysosomal storage disorder caused by mutations in the ARSA gene. While interventional trials often use untreated siblings as controls, the genotype-phenotype correlation is only ...
Saskia Elgün +10 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Global Ecology and ConservationPhenotypic diversity within a plant community can result from species diversity, genetic diversity and environmental variation. While phenotypic diversity mediated by species and genetic diversity can influence population structure and productivity, it ...
Xiao-Mei Zhang +6 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Phenotypic variation in Acidovorax citrulli.
, 2013 A. A phenotypic variant (PV) colony of strain M6 after 72 h of growth in NA. PV colonies of strain 7a1 have a similar appearance when observed at the naked eye. B.
Ram Kumar Shrestha (452925) +7 more
core +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Temporal phenotypic variation explained ratio of QTL function on PH at multiple stages.
, 2019 PVEU: phenotypic variation explanation ratio of unconditional QTL; PVEC: phenotypic variation explanation ratio of conditional QTL; DAE x: x days after emergence; The color picture can be downloaded in dio 10.1371/journal.pone.0224897.
Jie Song (60883) +10 more
core +1 more source