Results 161 to 170 of about 281,706 (265)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Structural Variants Contribute to Phenotypic Variation in Maize. [PDF]

Mol Ecol
Catlin NS, Agha HI, Platts AE, Munasinghe M, Hirsch CN, Josephs EB.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Methicillin-resistant <i>Staphylococcus aureus</i> has phenotypic variation in <i>mecA</i> expression that alters antibiotic sensitivity. [PDF]

Antimicrob Agents Chemother
Ma D, Arya R, Knapick BA, Sadaka NM, Rempuszewski J, Moul C, Mandell JB, Shah NB, Doub JB, Gish CG, Parker DM, Parvizi N, Sydlik SA, Wood HB, Rokes AB, Cooper VS, Richardson AR, Shanks RMQ, Urish KL.   +18 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

From malnutrition-related diabetes mellitus to 'type 5 diabetes': phenotypic variation, not reclassification. Reply to Gupta L, Misra A [letter]. [PDF]

Diabetologia
Trimble ER, Phillips DIW, Balcha SA.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Phenotypic Variation of 933 Broomcorn Millet (<i>Panicum miliaceum</i> L.) Germplasm Resources. [PDF]

Plants (Basel)
Kong Y, Zhang X, Li H, Qiu Y, Hou H, Zhang X, Feng B, Yang Q.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Phenotypic variation in otolith shape of American shad across eastern North American rivers. [PDF]

Sci Rep
Vasconcelos J, Limburg KE, Oterro-Ferrer JL, Tuset VM.   +3 more
europepmc   +1 more source