Results 191 to 200 of about 2,617,089 (305)

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Uncovering Phenotypic Variation in Common Bean (<i>Phaseolus vulgaris</i> L.): Insights from the INCREASE Project. [PDF]

Plants (Basel)
Hasanaklou HT, Sinkovič L, Papa R, Bitocchi E, Bellucci E, Dolničar P, Pipan B.   +6 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Characterization of disomic alien addition lines from an intersubgeneric cross between Glycine max and G. tomentella and phenotypic variation within those lines and their progenies. [PDF]

Plant Mol Biol
Wang S, Singh R, Battu G, Belaffif M, Clough SJ, Hudson M, Nelson R.   +6 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Sexual Dimorphism, Intrapopulation Phenotypic Variation and Matrilineal Genetic Diversity of <i>Naja kaouthia</i> Lesson, 1831 (Reptilia: Squamata: Elapidae) from Mizoram, Northeast India. [PDF]

Zool Stud
Biakzuala L, Lalremsanga HT.
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Phenotypic variation and genetic diversity assessment of proso millet (<i>Panicum miliaceum</i> L.) germplasm resources in northern Xinjiang. [PDF]

Front Plant Sci
Yun Z, Jun L, Hong-Jin W, Yang Z, Xiangwei H, Kuerban Z, Hui W, Baoyi Y, Guojun F, Bhanbhro N.   +9 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Methylome differences among barley inbreds and their association with genomic, transcriptomic, and phenotypic variation. [PDF]

J Exp Bot
Kühl M, Wu PY, Shrestha A, Engelhorn J, Mukherjee S, Hartwig T, Stich B.   +6 more
europepmc   +1 more source