Results 111 to 120 of about 194,178 (304)

Trajectories of persisting Covid- 19 symptoms up to 24 months after acute infection: findings from the Predi-Covid cohort study

BMC Infectious Diseases
Introduction Long COVID is a multisystemic, fluctuating condition inducing a high burden on affected people. Despite the existence of some guidelines, its management remains complicated.
Aurélie Fischer, Lu Zhang, Abir Elbéji, Paul Wilmes, Chantal J. Snoeck, Jérôme Larché, Pauline Oustric, Markus Ollert, Guy Fagherazzi   +8 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Groundnut (Arachis hypogaea L.) improvement in sub-Saharan Africa: a review

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2019
Groundnut (Arachis hypogaea L.) is a multi-purpose legume crop widely cultivated in sub-Saharan Africa (SSA). However, yield levels of the crop has remained relatively low in SSA owing to a range of biotic, abiotic and socio-economic constraints.
Seltene Abady, Hussein Shimelis, Pasupuleti Janila, Jacob Mashilo   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

M3P: The "Montpellier Plant Phenotyping Platforms"

, 2015
The research group LEPSE, ranked among the top 5% research group in ecophysiology worldwide in 2014 by a panel of experts is developing high throughput phenotyping platforms for more than 15 years.
Welcker, Claude, Tardieu, Francois, Negre, Vincent, Brichet, Nicolas, Suard, Benoit, Mineau, Jonathan, Dauzat, Myriam, Granier, Christine, Grau, Antonin, Cabrera Bosquet, Llorenç, Muller, Bertrand   +10 more
core  

High-resolution, time-lapse imaging for ecosystem-scale phenotyping in the field

, 2016
The high spatial and temporal resolution of data required for high-throughput phenotyping has typically been all but impossible to obtain in field populations of plants.
Borevitz, Justin, Brown, Timothy, Panneton, Whitney, Noah, Nina, Zimmermann, Christopher   +4 more
core   +1 more source

Analysis of small extracellular vesicles from dried blood spots

Frontiers in Medical Technology
This protocol paper describes how to extract small extracellular vesicles (sEVs) from dried blood spots (DBS). The methodology is described in detail and offers further evidence that the extracted particles are sEVs using western blotting (anti-CD9, CD63
Rikke Bæk, Jenni Kathrine Sloth, Mohammad Mehedi Hasan, Getnet Midekessa, Getnet Midekessa, Malene Møller Jørgensen, Malene Møller Jørgensen   +6 more
doaj   +1 more source

Digital Phenotyping

, 2022
This thesis is centered around the development and application of a digital platform for passive behavioral human subject research.This platform named Behapp (https://behapp.com), developed at the University of Groningen, makes use of mobile ‘apps’ to passively record various attributes related to social and explorative behavior through the smartphones
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source