Results 261 to 270 of about 1,168,358 (338)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PixlMap: A generalisable pixel classifier for cellular phenotyping in multiplex immunofluorescence images. [PDF]

PLoS One
Baird RL, Mason D, Rakovic K, Ballantyne F, Powley IR, Georgakopoulou A, Hillary L, Bird TG, Officer-Jones L, Le Quesne J.   +9 more
europepmc   +1 more source

A Computable Phenotype for Acute Respiratory Distress Syndrome Using Natural Language Processing and Machine Learning.

, 2018
Majid Afshar, Cara Joyce, Anthony Oakey, Perry Formanek, Philip Yang, Matthew M. Churpek, Richard Cooper, Susan Zelisko, Ron Price, Dmitriy Dligach   +9 more
openalex   +1 more source

Hypertriglyceridemic waist phenotype in primary health care: comparison of two cutoff points

, 2017
Marina Augusta Dias Braz, Jallyne Nunes Vieira, Flayane Oliveira Gomes, Priscilla Rafaella da Silva, Ohanna Thays de Medeiros Santos, Ilanna Marques Gomes da Rocha, Iasmin Matias de Sousa, Ana Paula Trussardi Fayh   +7 more
openalex   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Breaking the Stalemate: Advancing Sepsis Therapeutics Beyond Supportive Care. [PDF]

Public Health Rep
Strich JR, Teague HL, Yao X, Cruz RS, Childs RW.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The SINTER study: A Recall-by-Genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics

Koromani F, Huininga K, Li S, Trajanoska K, Berk K, Boon M, Chaker L, Daele Pv, Hofland J, Hoek Mv, Hemmelder M, Lennep JRv, Medici M, Olieman J, Ozcan B, Peeters R, Mattace-Raso F, Mulugeta E, Rossum EFv, Rooij Jv, Uitterlinden A, Visser W, Velsen EFv, Zillikens MC, Rivadeneira F.   +24 more
europepmc   +1 more source

From data to decisions: a paradigm shift in fruit agriculture through the integration of multi-omics, modern phenotyping, and cutting-edge bioinformatic tools. [PDF]

Front Plant Sci
Pacheco-Ruiz P, Osorio S, Vallarino JG.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source