Structural insights into copper and zinc binding to tau protein and the impact of metal binding on amyloid aggregation. [PDF]
Chem SciJuárez-Romero GU +8 more
europepmc +1 more source
Exploring the diversity of microbes and natural products from fungus-growing termite tripartite symbiosis. [PDF]
Eng MicrobiolShoaib M +5 more
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Catechol Oxidase and Phenoxazinone Synthase Activity of a Manganese(II) Isoindoline Complex
Journal of Inorganic Biochemistry, 2008The mononuclear [Mn(6'Me(2)indH)(H(2)O)(2)(CH(3)CN)](ClO(4))(2) (6'Me(2)indH: 1,3-bis(6'-methyl-2'-pyridylimino)isoindoline) complex has been prepared and characterized by various techniques such as elemental analysis, IR, UV-visible and ESR spectroscopy.
József Kaizer +2 more
exaly +3 more sources
Bis-Benzimidazole Diamide Iron(III) Complexes as Mimics of Phenoxazinone Synthase
Catalysis Communications, 2012 Abstract New Bis Benzimidazole diamide ligands-N,N′-Bis(2-Methylbenzimidazolyl) pyridinediamide [GBPA = L1] and N-Picolylated-N,N′-Bis(2-Methylbenzimidazolyl) hexandiamide [Pic-GBHA = L2] have been synthesized and utilized to prepare Fe(III) complexes. The X-ray structure of the ligand L2 crystallizes in the monoclinic space group P21/n.
Ravinder Kumar +2 more
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Phenoxazinone Synthase-like Activity of Rationally Designed Heme Enzymes Based on Myoglobin
Biochemistry, 2021The design of functional metalloenzymes is attractive for the biosynthesis of biologically important compounds, such as phenoxazinones and phenazines catalyzed by native phenoxazinone synthase (PHS). To design functional heme enzymes, we used myoglobin (Mb) as a model protein and introduced an artificial CXXC motif into the heme distal pocket by F46C ...
Li-Juan Sun +7 more
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Catechol Oxidase and Phenoxazinone Synthase: Biomimetic Functional Models and Mechanistic Studies
Coordination Chemistry Reviews, 2016Abstract The impetus to modeling of enzyme active sites comes from their potential to provide insight to the mechanistic pathways of the native enzymes, establish the role of that particular metal in the active site and to design better catalysts inspired by nature.
Suman Kr Dey, Arindam Mukherjee
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Syntheses, Structures and Phenoxazinone Synthase Activities of Two Cobalt(III) Complexes
ChemistrySelect, 2016Abstract A mononuclear complex, [LCo(L′) 2 ]ClO 4 ⋅MeOH⋅H 2 O ( 1 ) ( L′ =4‐aminopyridine) and a binuclear ...
Mamata Mahato, Hari Pada Nayek
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Cu(II)-Based Nanofibrous Metallogel for Phenoxazinone Synthase-like Activity
ACS Applied Nano Materials, 2021Metallogel formation by an individual ligand is well known, but simultaneous need of two ligands in selective metallogelation is relatively less common.
Sougata Sarkar +6 more
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Journal of Coordination Chemistry, 2018 Two new complexes, [MnL2](ClO4) (1) and [CuL2] (2) (where LH = (E)-1-((3-(dimethylamino)propylimino)methyl)naphthalen-2-ol), have been synthesized and characterized by spectroscopic techniques and their molecular structures are established by single ...
Swaraj Sengupta +2 more
exaly +2 more sources
Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin
Biochemistry, 1989Phenoxazinone synthase is a copper-containing oxidase that catalyzes the coupling of 2-aminophenols to form the 2-aminophenoxazinone chromophore. This reaction constitutes the final step in the biosynthesis of the potent antineoplastic agent actinomycin. The mechanism of this complex 6-electron oxidation was determined by using a variety of substituted
C E, Barry, P G, Nayar, T P, Begley
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