Results 91 to 100 of about 192,271 (214)

De Novo Design of Multivalent α/β‐Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain

Chemistry – A European Journal, EarlyView.
A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián, Vencel L. Petrovicz, Edit Wéber, Tamás A. Martinek, Zsófia Hegedüs   +4 more
wiley   +1 more source

Integrating Functional Consequence Annotation With PAH Allelic Phenotype Values Refines Prediction of Tetrahydrobiopterin Responsiveness. [PDF]

J Inherit Metab Dis
Himmelreich N, Blau N.
europepmc   +1 more source

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, EarlyView.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

<i>N</i>-acetylglucosamine regulates the siderophore lysochelin production through inducing the <i>p</i>-hydroxybenzaldehyde biosynthesis in <i>Lysobacter</i> sp. 3655. [PDF]

Front Microbiol
Jiang L, Yan X, Zhang F, Chen A, Chen Y, Zheng Y, Yu L.   +6 more
europepmc   +1 more source

A Selectfluor‐based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Chemistry – A European Journal, EarlyView.
Starting from carboxylic acids and Selectfluor‐derivatives, functionalized diazabicyclooctanes can be obtained via a novel Polonovski‐type rearrangement proceeding under mild reaction conditions. Besides their use in organic synthesis the unique structure and reactivity of the rearrangement products enables applications in medicinal chemistry ...
Jakob Kuhn, Susanne Gradl, Vanessa Osterloh, Peter Gmeiner, Harald Hübner, Markus R. Heinrich   +5 more
wiley   +1 more source

Structures of the neutral amino acid transporter LAT4 provide insights into antitumor effects of its inhibitor tubeimoside-1. [PDF]

EMBO J
Ding D, Lu Y, Yang J, Chen H, Jiang P, Jin Y, Luo J, Wang G, Yin Y.   +8 more
europepmc   +1 more source

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A

Chemistry – A European Journal, EarlyView.
A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger, Maxim Munt, Le Chang, Rositsa Stoykova, Roberto Ojcius, Oliver Spieß, Dieter Schinzer   +6 more
wiley   +1 more source

Transcriptome-metabolome integration reveals MYB/WRKY-RGA network and phenylalanine metabolism in potato late blight resistance. [PDF]

BMC Plant Biol
Liu X, Zou H, Li H, Fan Z, Fan X, Zhu Y, Chen Q, Hu R.   +7 more
europepmc   +1 more source

Amino Acid Modified Polymer Mesh for Removal of the Heavy Metal Ions Pb2+, Hg2+, Cu2+, and Ni2+ From Aqueous Solutions

Chemie Ingenieur Technik, EarlyView.
Adsorbents for cations of copper, lead, mercury, and nickel are obtained via grafting polymer mesh with an acrylic acid copolymer and subsequent functionalization with an amino acid. A distinct influence of the type of amino acid on the adsorption occurs.
Claudia Adolfs, Jan Becker, Hoang‐My Pham‐Cong, Uwe Gohs, Axel Fischer, Marco Drache, Sabine Beuermann   +6 more
wiley   +1 more source

Comparative Analysis of Dietary Patterns in Children With Phenylketonuria Phenotypes and Controls: Implications for Nutritional Status. [PDF]

J Inherit Metab Dis
Garcia-Arenas D, Ormazabal A, Isern P, Barrau-Martinez B, Gonzalez-Rodriguez A, Tor-Roca A, Llorach R, Campistol-Plana J, Urpi-Sarda M, Consortium PKU.cat..   +9 more
europepmc   +1 more source