Results 121 to 130 of about 232,397 (303)

Effect of large neutral amino acids treatment on blood phenylalanine, tyrosine, and tryptophan levels in adolescent and young adult PKU patients

Trends in Pediatrics
Objective: We aimed to evaluate the change in phenylalanine (Phe), Tyrosine (Tyr), and Tryptophan (Trp) blood levels in classical PKU patients treated with large neutral amino acids (LNAA) supplementation.
Fehime Erdem, Ebru Canda, Havva Yazıcı, Yasemin Atik Altınok, Merve Yoldaş Çelik, Ayşe Yüksel Yanbolu, Sema Kalkan Uçar, Sara Habif, Mahmut Çoker   +8 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Transient brain structure changes after high phenylalanine exposure in adults with phenylketonuria.

Phenylketonuria is a rare metabolic disease resulting from a deficiency of the enzyme phenylalanine hydroxylase. Recent cross-sectional evidence suggests that early-treated adults with phenylketonuria exhibit alterations in cortical grey matter compared ...
Everts, Regula, Hochuli, Michel, Muri, Raphaela, McKinley, Richard, Wiest, Roland, Trepp, Roman, Maissen-Abgottspon, Stephanie, Kreis, Roland, Rummel, Christian, Rebsamen, Michael, Pospieszny, Katarzyna, Radojewski, Piotr   +11 more
core   +1 more source

phenylalanine metabolism-html

, 2014
unigenes associated with phenylalanine ...
Karen Fugate (480954)
core   +1 more source

Relationship Between Gut Microbiota and Phenylalanine Levels: A Mendelian Randomization Study

MicrobiologyOpen
The specific members of the gut microbiota linked to phenylketonuria remain to be identified. This study aimed to assess the association between gut microbiota on phenylalanine (Phe) levels using a two‐sample Mendelian randomization (MR) approach ...
Zhijuan Liu, Minggang Ye, Huiya Jin, Weixia Chen, Hasitiyaer Jieens, Rui Han   +5 more
doaj   +1 more source

Spin‐Selective Oxygen Evolution in Chiral Molecule‐Intercalated Layered Double Hydroxides

Advanced Science, EarlyView.
This hybrid electrocatalyst utilizes chiral phenylalanine intercalation within layered double hydroxides to boost oxygen evolution. Acting as a spin filter via the chiral‐induced spin selectivity effect, the material directs electron transfer along a lower‐energy pathway.
Chih‐Ying Huang, Cheng‐Rong Wu, Yang‐Sheng Lu, Yu‐Ying Chang, Chia‐Che Chang, Tsung‐Hsin Liu, Che‐Lun Lee, Jessie Shiue, Yu‐Chang Lin, Wei‐Tsung Chuang, Huang‐Ming Tsai, Ya‐Lun Ho, Jau‐Wern Chiou, Hua‐Shu Hsu, Shao‐Sian Li, Chia‐Chun Chen, Way‐Faung Pong, Chun‐Wei Chen   +17 more
wiley   +1 more source

Successful Management of Two Consecutive Pregnancies With Maternal–Fetal Phenylketonuria: Lessons From Clinical Practice

JIMD Reports
Phenylketonuria (PKU) is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH), leading to the accumulation of phenylalanine (Phe) and an increased risk of developmental disorders.
Per Lundkvist, Karin Blom Malmberg, Linda Lindström, Andreas Kindmark   +3 more
doaj   +1 more source

Ultrasound-Enhanced Gelation of Stimuli-Responsive and Biocompatible Phenylalanine-Derived Hydrogels

Gels
Stimuli-responsive materials, particularly supramolecular hydrogels, exhibit a dynamic adaptability to external factors such as pH and ultrasound.
Eduardo Buxaderas, Yanina Moglie, Aarón Baz Figueroa, Juan V. Alegre-Requena, Santiago Grijalvo, César Saldías, Raquel P. Herrera, Eugenia Marqués-López, David Díaz Díaz   +8 more
doaj   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Conformational selection turns on phenylalanine hydroxylase

, 2018
Phenylalanine hydroxylase catalyzes a critical step in the phenylalanine catabolic pathway, and impairment of the human enzyme is linked to phenylketonuria.
Huang, Xuhui, Wang, Wei, Konovalov, Kirill A.   +2 more
core   +1 more source